Project Grant K24HL183909

The National Heart, Lung, and Blood Institute awarded The Trustees of Columbia University in the City of New York $133,221 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and validate precision electrophysiology imaging techniques for localizing cardiac arrhythmias.

The recipient will use computed tomography and echocardiography imaging combined with electroanatomical mapping data to create three-dimensional visualization of arrhythmia mechanisms. The work validates predictive imaging models against high-density activation maps acquired during invasive electrophysiology studies, with three proposed aims: providing target localization to improve procedural planning, determining how structural alterations such as scar, fibrosis, fat, and chamber dilatation affect electromechanical coupling, and quantifying pathophysiological features including left atrial tissue thickness, chamber volume, conduction velocity, voltage distribution, and electrogram characteristics. The project builds on ten years of collaborative development between Columbia's cardiac electrophysiology and biomedical engineering teams.

Performance occurs in New York, New York, with a period of performance from September 1, 2026, through August 31, 2031. This is a Project Grant, the assistance type for investigator-initiated research.