This is a Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System Incorporated. The $131,783 award will fund a 5-year research project focused on:
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Developing and implementing a protocol to collect biospecimens before and after bronchoscopic lung volume reduction (BLVR) procedures and other bronchoscopy procedures, to identify blood and bronchoalveolar lavage fluid biomarkers associated with COPD phenotypes and exacerbations.
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Identifying clinically relevant COPD subtypes and blood biomarkers associated with disease progression in the ongoing COPDGene study.
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Mentoring physician-scientists in patient-oriented research activities such as subject enrollment, sample collection, and omics data analysis for new and ongoing COPD studies.
The project aims to advance understanding of COPD disease heterogeneity, progression, and exacerbations, while training the next generation of researchers in patient-oriented respiratory disease research. The award began on February 1, 2025 and is scheduled for completion on December 31, 2029.
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