Project Grant K23NS151760
- The National Institute of Neurological Disorders and Stroke awarded Emory University $635,512 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate an automated deep brain stimulation programming platform for patients with Parkinson's disease. The project will develop machine learning algorithms and a closed-loop automated system to optimize deep brain stimulation parameters—including contact...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $469,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Michigan Technological University. The grant, titled "Dissecting Neural Circuit Mechanisms Underlying Pallidal Deep Brain Stimulation," will fund research to identify the neural elements and circuits necessary for the therapeutic effects of deep brain stimulation (DBS) of the globus...
- The National Institute of Neurological Disorders and Stroke awarded The Cleveland VA Medical Research & Education Foundation $330,000 on August 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate subthalamic deep brain stimulation for resolving visuo-vestibular conflict in Parkinson's disease. The research aims to optimize subthalamic nucleus DBS to enhance self-motion perception and visuo-spatial navigation...
- The National Institute of Neurological Disorders and Stroke awarded $597,934 to The University of Texas Southwestern Medical Center on March 22, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to dissect the network physiology of pallidal burst stimulation for Parkinson's disease deep brain stimulation (DBS) therapy. The recipient will analyze basal-ganglia-thalamo-cortical motor circuits through intracranial recordings of...
- The National Institute of Neurological Disorders and Stroke awarded Brigham & Women's Hospital Inc. $557,883 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating pathogenic mechanisms of leucine-rich repeat kinase 2 (LRRK2) mutations linked to familial Parkinson's disease, dementia with Lewy bodies, and tauopathies. The research examines whether mitochondrial and...
- The National Institute of Neurological Disorders and Stroke awarded The University of Iowa $597,466 on September 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate dopamine circuitry underlying executive dysfunction in Parkinson's disease. The research maps how dorsomedial striatal dopamine engages medium-spiny neuron ramping activity during interval timing, an elementary executive process impaired in patients with...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $540,901 on April 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate molecular mechanisms underlying dopamine signaling dysfunction in advanced Parkinson's disease. The research examines how striatal projection neurons become maladaptive during disease progression and why L-DOPA therapy loses efficacy over time. The work focuses...
- The National Institute of Neurological Disorders and Stroke awarded the University of Pittsburgh a cooperative agreement totaling $312,858 on September 1, 2026, to test the safety, feasibility, and early efficacy of deep brain stimulation of the motor thalamus to improve speech intelligibility in people with chronic post-stroke dysarthria. The award funds research under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). The project will...
- The National Institute of Neurological Disorders and Stroke awarded Brigham & Women's Hospital Inc. $681,377 on August 24, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the neuroinflammatory and metabolomic mechanisms by which the gut microbiome modulates Parkinson's disease dementia. The funded research examines how specific gut microbiota contribute to Parkinson's disease versus Parkinson's disease dementia...
- The National Institute of Neurological Disorders and Stroke awarded The Washington University $163,079 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on cerebrospinal fluid and skin biomarkers of cognitive decline in Parkinson disease and Lewy body dementia. The research validates candidate synaptic protein biomarkers (neuronal pentraxin 2 and somatostatin) in cerebrospinal fluid that may...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded Brigham & Women's Hospital $230,580 on September 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct investigator-initiated research on circuit-based deep brain stimulation (DBS) reprogramming for cognitive impairment in Parkinson's disease patients. The research addresses cognitive decline that may follow DBS surgery, a common and effective treatment for Parkinson's motor symptoms. Prior studies demonstrated that DBS electrode placement more connected to a cognitive circuit—comprising the anterior cingulate, caudate nucleus, hippocampus, and cognitive regions of the cerebellum—correlates with diminished global cognitive status one year post-surgery. The investigators identified an algorithm to determine the cognitively optimal DBS contact configuration for individual patients by minimizing connectivity to the cognitive circuit while preserving motor benefit. The study will evaluate whether connectivity between the cognitive circuit and the motor-optimal DBS configuration correlates with global and domain-specific cognitive status using the Dementia Rating Scale-2 and neuropsychological test battery. A second aim will assess whether connectivity-based DBS reprogramming improves cognitive task performance while maintaining motor benefits. The research draws on a cohort of 120 Parkinson's disease patients with DBS electrodes localized at Brigham & Women's Hospital in Boston, followed 0.5 to 10 years post-surgery. The award period runs through July 31, 2031, with place of performance in Boston, Massachusetts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $230.6k | 9/2/26 |