Project Grant K23NS151025
- The National Institute of Neurological Disorders and Stroke awarded The Washington University $618,108 on June 18, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on neuroinflammation in cerebral small vessel disease, a leading vascular contributor to cognitive impairment and dementia. The recipient will evaluate the relationship between 11C-CS1P1 PET uptake—a novel positron emission tomography radiotracer...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $627,103 to the Research Foundation For Mental Hygiene, Inc. on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The Research Foundation For Mental Hygiene, Inc., operating through its New York State Psychiatric Institute division, will investigate the role of the adaptive...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $927,014 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to validate a diagnostic lipid biomarker panel for idiopathic Parkinson's disease. The R61 phase of this project will develop a quantitative liquid chromatography-mass spectrometry assay for eight lipid biomarkers discovered in red blood cells that distinguish idiopathic...
- The National Institute of Neurological Disorders and Stroke awarded Northwestern University $566,529 on April 24, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate age-related deficits in trophic support of dopamine neurons in preclinical models of Parkinson's disease. The research examines cell-type-specific alterations in LRRK2G2019S mice to determine how the LRRK2 mutation affects neuroprotective signaling...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded $671,445 to Weill Medical College of Cornell University on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds development of an integrated pipeline for early Parkinson's disease prediction and disease-modifying drug repurposing. The work targets the...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Colorado State University $635,317 on September 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing R01NS151727) to investigate how fibril structure of alpha-synuclein strains affects disease pathogenesis in synucleinopathies. The research addresses disease...
- The National Institute of Neurological Disorders and Stroke awarded Northwestern University $634,938 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate RNA editing dysregulation in dementia with Lewy bodies and Parkinson's disease. The research addresses how proteostasis failure in these neurodegenerative conditions leads to accumulation of nuclear inclusions containing RNA binding proteins NONO and SFPQ,...
- The National Institute of Neurological Disorders and Stroke awarded Brigham & Women's Hospital Inc. $557,883 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating pathogenic mechanisms of leucine-rich repeat kinase 2 (LRRK2) mutations linked to familial Parkinson's disease, dementia with Lewy bodies, and tauopathies. The research examines whether mitochondrial and...
- The National Institute on Aging awarded The Washington University $427,625 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate orexin signaling pathways as a potential mechanism to prevent alpha-synucleinopathies including Parkinson's disease and dementia with Lewy bodies. The funded research examines whether orexin gene deletion enhances microglial engulfment of alpha-synuclein and mitigates pathology in mouse models. Washington University will perform detailed...
- The National Institute of Neurological Disorders and Stroke awarded Duke University $1.806 million on May 11, 2026, under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) to investigate LRRK2 signaling in the progression of Parkinson's disease and dementia. The research applies ultra-sensitive single molecule array assays to assess LRRK2 signaling—specifically phosphorylation of the RAB10 substrate—in biobanked tissues and fluids from Parkinson's disease...
The National Institute of Neurological Disorders and Stroke awarded The Washington University $163,079 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on cerebrospinal fluid and skin biomarkers of cognitive decline in Parkinson disease and Lewy body dementia. The research validates candidate synaptic protein biomarkers (neuronal pentraxin 2 and somatostatin) in cerebrospinal fluid that may correlate with cognitive impairment and predict conversion to dementia in Parkinson disease patients. The work identifies and validates additional candidate synaptic proteins across multiple cerebrospinal fluid cohorts using proteomic and immunoassay approaches. The study also assesses phosphorylated alpha-synuclein in skin biopsies as a potential biomarker of cognitive impairment and decline, hypothesizing that skin phosphorylated alpha-synuclein levels reflect insoluble alpha-synuclein aggregates in the brain thought to be pathogenic in Parkinson disease and Lewy body dementia. Place of performance is St. Louis, Missouri. The period of performance runs from September 1, 2026, through August 31, 2031. The award leverages existing cerebrospinal fluid data collected through large-scale longitudinal studies with established funding. This is a Project Grant, a standard assistance type under NINDS extramural research programs, which support fundamental and translational research to reduce the burden of neurological disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $163.1k | 8/24/26 |