Project Grant K23HL179517
- This federal Project Grant award, valued at $158,652 and provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports research into the impact of alveolar macrophage senescence in aged donor lungs on post-lung transplant outcomes. The award, with a start date of September 1, 2025 and an ultimate completion date of August 31, 2030, will be carried out by Duke University's Office of Research Administration Division. The research aims to...
- This Project Grant award, provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports research on the use of donor-derived cell-free DNA for risk stratification and post-treatment monitoring of lung transplant patients at risk of chronic lung allograft dysfunction. The award, totaling $248,999.00, will be provided to the University of Maryland, Baltimore to fund this 3-year research project from July 2025 to May 2028. The project aims to...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $701,795 to The Trustees of the University of Pennsylvania to conduct research aimed at defining the cardinal functions of lung progenitors during regeneration. The 4-year project, which began in September 2025, utilizes a multi-modal approach including cell lineage tracing, single-cell analysis, histological spatial analysis, and cross-species comparison to...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $165,672 to New York University School of Medicine to conduct research aimed at increasing heart transplant (HT) volume in the United States. The key objectives are to: Investigate the impact of donor risk factors, such as coronary artery disease, left ventricular dysfunction, and older age, on post-HT outcomes using European and U.S. registry data. This...
- The University of Utah received a $782,289 project grant award from the National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) to develop machine learning models that incorporate donor lung CT images to predict the risk of severe primary graft dysfunction (PGD) in lung transplant recipients. The project aims to leverage a multi-center cohort of lung transplant data to build improved predictive models that fuse donor and recipient clinical data with...
- The National Heart, Lung, and Blood Institute (NHLBI), through its Cardiovascular Diseases Research (CFDA 93.837) program, awarded a $762,747 project grant to New York University (NYU) to develop engagement protocols for donor family members and healthcare staff during research involving the recently deceased. This research aims to advance the field of xenotransplantation, which uses organs from deceased humans maintained through medical interventions to test novel pharmaceuticals and medical...
- This Project Grant award of $147,486 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to investigate the role of inflammatory signaling in the migration and function of ectopic KRT5+ cells during severe respiratory viral injuries. The research will assess whether canonical NF-kB signaling is necessary for the expansion and migration of these ectopic cells, which have been associated with the development of pulmonary fibrosis following viral...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to Northwestern University provides $798,958 to conduct research on the molecular mechanisms underlying the link between primary graft dysfunction (PGD) and chronic lung allograft dysfunction (CLAD) after lung transplantation. The key objectives are to: 1) Determine whether activation of the integrated stress response (ISR) in the alveolar epithelium impairs repair after...
- The National Heart Lung and Blood Institute awarded a $719,882 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Regents of the University of California, San Francisco (UCSF) to elucidate lung-specific immune pathways driving post-hematopoietic cell transplant lung injury in children. The research aims to identify cellular and molecular targets for precision diagnostics and therapeutics. Specifically, the project will leverage bronchoalveolar lavage fluid...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $629,498 to The Trustees of the University of Pennsylvania (UEI GM1XX56LEP58) to conduct research aimed at deciphering the molecular mechanisms underlying pediatric interstitial lung disease (CHILD). The key objectives are to: Interrogate the anomalous development of the lung epithelium in CHILD by defining the impact of a specific SFTPC gene mutation on alveolar...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $174,420 to The Trustees of the University of Pennsylvania to conduct research aimed at improving lung transplantation outcomes. The key objectives are to investigate the impact of centralizing deceased organ donor management at specialized Donor Care Units (DCUs) and assess the consequences for diverse stakeholders in the national donation and transplantation system. The research will use advanced observational methods to analyze existing and prospectively collected data, with the goal of providing evidence to optimize the use of DCUs and improve access to this critical, limited treatment. The award period runs from September 1, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $174.4k | 8/28/25 |