This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $154,861 to Children's Research Institute to advance research on addressing social adversity and promoting health equity for children with asthma. The key objectives are to: 1) develop a machine learning model to predict hospitalization risk among children with asthma using social adversity, clinical, and demographic data from the...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 (Cardiovascular Diseases Research) provides $177,403.00 to Brigham & Women's Hospital Inc. to conduct research aimed at understanding the heterogeneity and endotypes of asthma. The 5-year project, starting on September 1, 2024, will leverage multi-omics data from three cohorts of asthmatic children to analyze the interplay between genetic, epigenetic, and metabolomic factors in...
This $171,450 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports a multi-omic investigation into the biological mechanisms linking excess body fat (adiposity) and elevated blood lipid levels as contributors to cardiovascular disease risk. The research, led by Dr. Dron at the Massachusetts General Hospital, aims to: (1) measure the interaction effects between adiposity and genetic factors on...
The federal Project Grant award K23HL174407, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate multifactorial determinants of asthma in underresourced pediatric populations. The $164,453 award to the Arkansas Children's Research Institute (ACRI) will examine asthma prevalence, morbidity, and healthcare utilization among racial/ethnic minority and rural children in Arkansas. By...
The Project Grant award K23HL163253, totaling $178,783, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award will support Dr. Pappalardo's research to understand barriers and develop targeted implementation strategies for school-based stock inhaler programs, with the goal of improving asthma management and reducing health disparities. The grant will fund a community-engaged, implementation science...
This Project Grant award for $167,001 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support the development of physiologically-based pharmacokinetic (PBPK) models to optimize dosing of common asthma medications in pregnant individuals. The principal investigator, Dr. Kathleen M. Job, will work with a team of experts in PBPK modeling, maternal-fetal medicine, and...
This $1,284,920 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports a multi-year study led by the Arkansas Children's Research Institute (ACRI) to optimize the use of a triple combination cystic fibrosis (CF) therapy. The study aims to: 1) analyze the pharmacokinetics of the three drug compounds in the therapy to determine their exposure-response relationship; 2) identify novel genetic variants...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $145,910 to The Children's Hospital of Philadelphia (CHOP) to conduct a prospective observational study on post-cardiac arrest myocardial dysfunction and inflammation in critically ill children. The study will leverage advanced echocardiographic imaging and biomarker assessment to examine associations between these measures and clinical...
This $274,392 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports a study on the social determinants of health (SDOH) and their impact on asthma-related morbidity and optimization of treatment for Black and Latinx adults with moderate-to-severe asthma. The key objectives are to: 1) determine if unique SDOH exposures within Black vs. Latinx racial/ethnic groups distinctly associate with worse...
The National Heart, Lung, and Blood Institute (NHLBI) awarded Emory University a $127,645 Project Grant under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) to enhance the university's ability to train, mentor, and support new investigators in patient-oriented research on early cardiometabolic disease in children. The 5-year grant, awarded on August 15, 2024, will fund research aimed at understanding the physiological changes in children that lead to metabolic...