This $600,761 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to understand the role of the NKG2D receptor and its ligands in driving lung inflammation and development of bronchopulmonary dysplasia (BPD) in preterm infants. The key objectives are to: 1) Investigate the contribution of NKG2D+ lung lymphocytes (gamma-delta T cells and NK cells) to LPS- and hyperoxia-induced lung...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $2,070,206 to Ann & Robert H Lurie Children's Hospital of Chicago to conduct research on endotypes of bronchopulmonary dysplasia (BPD) in premature infants. The research aims to leverage existing genetic and longitudinal clinical data from approximately 2,000 former premature children to characterize the long-term...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Federal Grant Program CFDA 93.837 - Cardiovascular Diseases Research, will establish patient-reported outcome measures to refine risk stratification and identify barriers to post-discharge specialty care for preterm infants with bronchopulmonary dysplasia (BPD). The $586,021 award to the Medical College of Wisconsin, Inc. will link neonatal intensive care unit data to mobile-enabled parent-reported...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $179,330 to the Research Institute at Nationwide Children's Hospital to conduct research aimed at identifying biomarkers that can predict disease progression and weaning outcomes in infants with severe bronchopulmonary dysplasia (BPD). The goal is to develop biomarker-informed prognostic models and assess the feasibility of a biomarker-driven clinical trial of...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $773,916 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Children's Hospital Medical Center in Cincinnati, Ohio. The 5-year grant, which runs from August 2024 to June 2029, aims to create and validate a tool to calculate the contribution of each phenotype of bronchopulmonary dysplasia (BPD) to elevated breathing effort, known as the work of breathing (WOB), in premature neonates. The research...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,505,110 to The Leland Stanford Junior University to conduct research on human pulmonary neuroendocrine cells (PNECs) and their stem cells. The key objectives are to map the innervation and molecular subtypes of human PNECs, identify their functional subsets, and characterize the cellular and molecular features of PNEC stem cells and their niches. This...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) will provide $1,159,870 over 5 years to Yale University to conduct research on therapeutic strategies for managing bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) in children. The key objectives of this award are to: (1) develop methods for predicting BPD-PH in preterm infants, (2)...
This federal Project Grant award for $177,721.00 was provided by the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research (CFDA 93.837) program. The award recipient is Brigham & Women's Hospital Inc., a prominent academic medical center and research institution in Boston, Massachusetts. The grant supports a research project led by Principal Investigator Nicole Prince, PhD, a biochemist with expertise in molecular epidemiology. The project aims to...
This federal Project Grant award of $200,502 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports a research project led by Dr. Narges Alipanah-Lechner at the University of California, San Francisco (UCSF). The project aims to identify metabolite and protein drivers of the evolution of Acute Respiratory Distress Syndrome (ARDS) subtypes, specifically the hyper-inflammatory and hypo-inflammatory forms. The research will utilize comprehensive...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 "Cardiovascular Diseases Research" will provide $126,059 from September 1, 2024 to August 31, 2029 to the University of Colorado-Denver. The project aims to use proteomics and metabolomics approaches to study the systems biology of acute and chronic multi-organ failure in children with congenital heart disease (CHD). Specifically, the project will measure changes in the circulating...