Project Grant K23HL168162
- This Project Grant award of $807,067.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support a study to pioneer the quantitative documentation of human respiratory kinematic profiles. The study aims to address a critical gap in contemporary physiological monitoring - the inability to quantify labored breathing, which contains vital prognostic information not captured by conventional monitoring. Building on a recent innovation called ARK...
- This federal Project Grant award of $169,344 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to advance the management of critically ill adults with non-ARDS acute hypoxemic respiratory failure (NAHRF). The key objectives are to: 1) Develop clinical prediction models for mortality in NAHRF patients; 2) Apply machine learning to detect NAHRF subphenotypes associated with differential clinical outcomes; and 3) Use sequencing-based whole...
- The National Heart, Lung, and Blood Institute (NHLBI), via the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $564,445 Project Grant to the University of Texas Health Science Center at Houston (UTHealth) to fund research on "Targeting Hypoxia-Inducible Factors (HIFs) for Heart and Lung Disease." The 6-year grant, starting on March 1, 2025 and ending on December 31, 2031, supports three complementary research projects focused on investigating the upstream regulation...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $144,989 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The General Hospital Corporation (doing business as Massachusetts General Hospital) to develop, train, and test deep generative models using computed tomography (CT) images to predict lung injury progression and treatment responses in patients with acute respiratory distress syndrome (ARDS). The goal is to leverage artificial intelligence and image...
- This federal Project Grant award of $738,154 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to develop a novel mortality risk prediction model to accurately assess mortality risk for ICU patients across all patient groups. The key objectives are to: (1) identify mechanisms of systematic measurement error in commonly used ICU mortality risk prediction models, and (2) develop an accurate ICU mortality risk prediction model. The project will...
- The University of Utah received a $782,289 project grant award from the National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) to develop machine learning models that incorporate donor lung CT images to predict the risk of severe primary graft dysfunction (PGD) in lung transplant recipients. The project aims to leverage a multi-center cohort of lung transplant data to build improved predictive models that fuse donor and recipient clinical data with...
- This $1,380,474 federal Project Grant awarded on September 24, 2025 by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to improve the care of patients with acute heart and lung diseases. The University of Michigan will develop data-driven models to support improved decision-making for intensive care unit (ICU) triage and inpatient bed assignment. The project will identify determinants of triage and bed assignment, develop a clinical decision...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $737,815 to The Washington University in St. Louis to develop and validate an automated electronic health record (EHR)-embedded system that can classify molecular phenotypes of acute respiratory distress syndrome (ARDS) and sepsis at the bedside. The primary objective is to translate advanced research on ARDS and sepsis heterogeneity into clinical...
- This federal Project Grant award, valued at $272,226.00, was granted by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The project aims to determine how clinician and scheduling characteristics impact patient outcomes, and explore the moderating effect of patient characteristics on these relationships, for mechanically ventilated adults in intensive care units. The project will conduct a novel secondary analysis utilizing a unique...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to advance precision medicine for Acute Respiratory Distress Syndrome (ARDS) and sepsis. The $2,295,984 award to the University of California, San Francisco (UCSF) will fund research to address critical unanswered questions about the distinct molecular phenotypes of ARDS and sepsis, and how to optimize real-time phenotyping and integrate analyses of phenotype-specific...
This Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $186,408 to the University of Washington to develop robust models that identify patients at high risk for persistent hypoxemic respiratory failure (HRF). The goal is to improve the ability to distinguish patients with persistent HRF early, which is critical for enrolling the highest-risk patients in clinical trials for new HRF therapies. The project will integrate data from electronic health records, chest radiograph reports, and banked blood samples to create predictive models, and will also explore novel methods to analyze chest radiograph images and tracheal aspirates to further enhance prediction. This work aims to yield improved models for identifying patients most likely to benefit from new interventions for acute hypoxemic respiratory failure, a condition with limited treatment options and high mortality rates. The award period is from September 1, 2025 to August 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $186.4k | 8/13/25 |