Project Grant K23EY037861
- This $638,625 Project Grant awarded by the National Eye Institute (CFDA 93.867 - Vision Research) to the University of California, San Diego (UC San Diego) aims to investigate the mechanism of drusen formation in age-related macular degeneration (AMD). The research will utilize a novel Bruch's membrane-on-a-chip assay developed by the university to study the retention of lipoproteins in the extracellular matrix, which is believed to contribute to drusen accumulation in the early and intermediate...
- This $231,000 Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), will fund the development of a generalized deep learning platform to improve the objectivity, reproducibility, and accuracy of quantifying and assessing experimental autoimmune uveitis (EAU) - a valuable animal disease model for studying human uveitis. The project aims to generate high-quality, well-annotated multi-modal datasets from three independent research...
- This Project Grant award, totaling $620,149, was provided by the National Eye Institute under the Vision Research federal grant program (CFDA 93.867) with a performance period from April 1, 2025 to March 31, 2030. The University of Iowa will conduct base editing and prime editing of risk loci in human cells, including iPSC-derived retinal pigment epithelium, retina, and choroid, as well as donor retinal and choroidal explant cultures. The goal is to address fundamental scientific questions...
- This Project Grant award of $253,500.00 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research by the Icahn School of Medicine at Mount Sinai to reconstruct a human blood-retina barrier and perfused vascular system. The goal is to investigate the role of apolipoprotein E (APOE) variants in age-related macular degeneration (AMD), a leading cause of vision loss. The researchers will optimize an in vitro human outer blood-retina barrier model to study AMD phenotypes and...
- This Project Grant award from the National Eye Institute's Vision Research program (CFDA 93.867) provides $179,964 to the University of California, Irvine (UCI) to develop innovative biomarkers for optic neuropathies using deep learning-based analysis of optical coherence tomography (OCT) imagery. The project aims to overcome limitations of current OCT-based diagnostics by employing advanced computational techniques like deep learning, neural fields, and geometric modeling to enhance the...
- This federal Project Grant award of $240,713 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research into the role of the nuclear-encoded humanin isoform MTRNR2L1 in age-related macular degeneration (AMD). The awardee, The Research Foundation for the State University of New York (RF SUNY), will investigate whether MTRNR2L1 is a protein-coding gene or a long non-coding RNA, and examine its function in regulating mitochondrial activity and cell...
- This federal Project Grant award of $675,193 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research at Duke University on gene therapy targeting complement factor H (CFH) and lipoprotein dynamics in age-related macular degeneration (AMD). The research aims to leverage novel animal models that integrate advanced age, complement dysregulation, and lipid/cholesterol perturbation to understand the contributions of these factors to AMD pathogenesis. The award period runs...
- This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) is providing $658,889 to the University of Rochester to investigate the role of the secretory phospholipase A2-IIA (PLA2G2A/sPLA2-IIA) enzyme in the development of age-related macular degeneration (AMD). The research aims to critically evaluate the pathogenic role of PLA2G2A in AMD using human donor eyes, patient-derived induced pluripotent stem cells, and transgenic mouse models. The ultimate goal...
- This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $654,455 to The Leland Stanford Junior University to develop fair and generalizable artificial intelligence (AI) algorithms for predicting glaucoma progression. The goal is to address racial/ethnic disparities in the performance of these AI models, which disproportionately impact minority populations. The research involves comparing fairness-aware algorithm training methods, evaluating model...
- This $1,813,621 Project Grant was awarded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to support a research project titled "Nutritional Metabolomics in Age-Related Macular Degeneration and Retinal Integrity". The grant, awarded to The Research Foundation For The State University Of New York (RF SUNY), will fund the analysis of approximately 2,000 metabolites from participant serum samples to examine the relationship between...
This $244,379 Project Grant award from the National Eye Institute's Vision Research program (CFDA 93.867) supports research at the University of California, Los Angeles (UCLA) to explore how genetic variation influences disease progression and treatment response in age-related macular degeneration (AMD), a leading cause of vision loss. The project aims to leverage machine learning (ML) and artificial intelligence (AI) techniques to analyze optical coherence tomography (OCT) imaging data and refine the classification of AMD subtypes. This will enable a deeper understanding of how genetic factors shape AMD progression rates and treatment outcomes. The research will utilize datasets from the UK Biobank and UCLA Biobank, with the goal of improving polygenic risk score models to better predict rapid AMD progression and treatment responsiveness. The award period runs from September 2025 through March 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $244.4k | 9/10/25 |