Project Grant K23DK146169
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded $2,076,999 to the University of Colorado-Denver on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for a four-year project period extending through September 14, 2029. This Project Grant supports basic biomedical research investigating the role of mitochondrial dysfunction in Paneth cells as a mediator of inflammatory...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Children's Hospital Corporation, doing business as Boston Children's Hospital, $167,060 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant K08DK143340). The award funds research on defective STAT3 signaling in very early-onset inflammatory bowel disease patients, with the objective of linking molecular pathways to precision-based...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Massachusetts General Hospital $835,752 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop molecular magnetic resonance imaging techniques for non-invasive assessment of inflammatory activity in inflammatory bowel disease. The project aims to create a rapid, sensitive imaging test that evaluates intestinal inflammation anywhere in the...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Trustees of Boston University $703,748 on April 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of bacterial polyphosphates in intestinal immune networks and inflammatory bowel disease pathogenesis. The research will elucidate how bacterial polyphosphates—long-chain polymers with roles in prokaryotic virulence and host evasion—exacerbate...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $356,328 to Celdara Medical, LLC on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop a novel allogeneic cell therapy for difficult-to-treat inflammatory bowel disease. Celdara will develop cell-based therapeutic candidates targeting the dysregulated immune response in IBD patients who fail multiple lines of conventional therapy or experience...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Boston Children's Hospital $831,433 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supporting research to redefine the biogeography and function of food proteins in human health and disease. The project establishes first principles of the food-host interactome by developing systematic approaches to map the transit, transformation, and tissue...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Washington $825,905 on March 6, 2026, to develop an immunocompetent colon chip platform for modeling Crohn's disease under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research). The award funds construction of a three-dimensional intestinal platform incorporating primary intestinal and immune cells to model the colonic microenvironment in both health and disease. The platform...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Johns Hopkins University $1,427,080 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate aberrant N-glycosylation in Crohn's disease as a pathway to precision medicine therapeutics. The research examines how defective N-glycosylation exacerbates Crohn's disease in patients carrying a pathogenic mutation in the manganese transporter ZIP8...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Mayo Clinic $694,443 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop and validate advanced ultrasound imaging biomarkers for Crohn's disease. The award funds development of multiparametric ultrasound imaging technology combining B-mode imaging, advanced microvessel imaging technology, and echo statistical features to assess bowel inflammation and...
- Federal Project Grant Award Summary The University of Colorado-Denver received a $234,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 15, 2025, through September 14, 2027. The award funds research investigating the role of AIOLOS, a transcriptional repressor protein, in T cell-mediated pathogenesis of inflammatory bowel...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Brigham and Women's Hospital Inc. $193,776 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify cytokine biomarkers that predict response to IL-23 p19 inhibitor therapies for inflammatory bowel diseases, including Crohn's disease and ulcerative colitis. The research will quantify cytokines related to IL-23 signaling in serum and inflamed intestinal mucosa to identify individuals most likely to respond to therapies targeting this pathway, with the goal of reducing costs associated with trial-and-error approaches to advanced therapy selection and shortening time to remission. The work also evaluates the efficacy of dose intensification after loss of response to p19 inhibitors to define new treatment targets and guide optimal positioning of these drugs relative to other advanced therapies. Performance takes place in Boston, Massachusetts, with a period of performance from September 1, 2026, through July 31, 2031. The award carries the assistance type designation of Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $193.8k | 8/20/26 |