Project Grant K23DE035217

Award Date 7/1/25
Completion Date 6/30/30
Dollars Obligated $162K
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Washington, USA
Similar Awards
This $183,817 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), aims to investigate how specific anatomical features in infants with cleft palates can predict surgical procedures and impact speech development. The proposed research by the University of Wyoming will enroll 30 infants before their palate repair surgery at 10 months old and follow them until...
This federal Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), will support a comprehensive research study on addressing undernutrition in infants born with orofacial clefts in the United States. The $5,709,807 grant, awarded to Seattle Children's Hospital, will leverage data from a large clinical retrospective cohort study as well as a prospective cohort study to: 1) predict...
This federal Project Grant award, valued at $645,034 and provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to leverage whole genome sequencing and functional genomic characterization to improve gene discovery for non-syndromic cleft lip and palate (NSCLP). The University of Pittsburgh, the prime recipient, will integrate gene- and variant-based analyses of large,...
This Project Grant award of $537,163, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports a longitudinal study investigating the effects of anesthesia exposure and oxygen saturation on brain structure/function and pre-speech/language development in infants with isolated cleft lip and/or palate (ICL/P). The study aims to assess the impacts of desaturation events and anesthesia exposure on...
This federal Project Grant award, valued at $129,420.00 and funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to improve bone regeneration for cleft palate repair. The research aims to: 1) Identify how skeletal stem cell subpopulations and bone morphogenetic protein receptor (BMPR) usage differences between palatal and mandibular bone contribute to varied bone regeneration...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $154,602.00 to the University of Pittsburgh to study the molecular mechanisms and cellular changes underlying cleft lip and palate birth defects. The research aims to: 1) understand the epigenetic modifications that affect the WNT9B gene and its role as a modifier of the cleft lip phenotype in a mouse model, and...
The federal Project Grant award R35DE034346, totaling $320,053, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The award supports comprehensive research at the University of Southern California (USC) to investigate the mechanisms regulating the assembly and maintenance of the craniofacial skeleton, a multi-tissue system composed of diverse connective tissues and bone. The research program...
This federal Project Grant award in the amount of $455,939.00 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to investigate the molecular and cellular mechanisms underlying craniofacial defects related to FGF8 signaling. The research, conducted by the University of Massachusetts Lowell, aims to better understand how the first pharyngeal pouch and cleft development regulated by FGF8...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), will fund research to elucidate the molecular mechanisms underlying cleft lip, a common craniofacial birth defect. The $178,848 award will be provided to The Regents of the University of California, San Francisco (UCSF) over a 5-year period from August 1, 2024 to July 31, 2029. The research will leverage newly...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $452,681 Project Grant (R01DE033885) under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121) to The Regents of the University of California, San Francisco (UCSF). The grant supports research to determine the tissue-specific roles of the ESCRT machinery in regulating signaling pathways and lipid metabolism during mammalian craniofacial morphogenesis. Key objectives include characterizing...

This federal Project Grant award, with a total funding amount of $161,644, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The award supports a prospective cohort study of 50 adolescents and young adults with cleft palate to investigate the anatomic risk factors associated with post-operative velopharyngeal insufficiency (VPI), quantify the relationship between speech measures and patient-reported outcomes, and discover patient perspectives on jaw surgery. The principal investigator, Dr. Sara Kinter, is an assistant professor, epidemiologist, and speech-language pathologist at the University of Washington's Department of Pediatrics, Division of Craniofacial Medicine. The study will be conducted at Seattle Children's Hospital, a leading pediatric research and healthcare institution. The research aims to further illuminate the risks and benefits of maxillary advancement surgery on speech outcomes, which is critical to informing future surgical decisions for this patient population.

Generated 6/24/25, 3:41 AM