This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to define the contribution of Schwann cells and the transient receptor potential vanilloid subtype 4 (TRPV4) ion channel to oral cancer pain mechanisms. The $162,743 award to New York University (NYU) aims to develop and validate assays of pressure and stretch sensitivity, investigate the impact of TRPV4 deletion in Schwann cells on orofacial functional pain, and study the effects of trigeminal neuronal hyperexcitability induced by pressure and stretch on oral cancer. The research will help improve understanding of peripheral TRPV4 signaling in oral cancer pain, with the potential to inform the development of novel TRPV4 antagonist analgesics for alleviating pain in oral cancer patients. The project period extends from March 10, 2025 through February 28, 2030.
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