This $299,820 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund a feasibility study on a telehealth-delivered mindful exercise intervention for people with knee osteoarthritis. The study aims to determine the feasibility of the mindful exercise program compared to telehealth-delivered exercise alone, as well as the feasibility of...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1,066,302 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to the University of Massachusetts Medical School. The grant, effective April 1, 2025 through March 31, 2029, will fund the creation of a biomedical knowledgebase to promote and facilitate the use of the Osteoarthritis Initiative (OAI), a rich 16-year observational study with comprehensive...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is funding research to investigate the mechanistic links between gait biomechanics and the development of knee osteoarthritis (KOA). The $644,152 award, which runs from January 2025 to December 2029, will be used by the University of North Carolina at Chapel Hill to: 1) determine the acute in vivo...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $123,040 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to investigate the therapeutic role of the NFAT1 transcription factor in osteoarthritis. The 5-year project, which began on August 1, 2024, aims to evaluate the potential of AAV-delivered NFAT1 gene therapy in treating...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $393,883 to Wake Forest University to conduct research on muscle power as a predictor of knee osteoarthritis in at-risk females. The primary aim is to determine if baseline levels of maximal knee extensor muscle power can predict the incidence of structural knee osteoarthritis, as...
This federal Project Grant award of $221,866.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to examine the association between alcohol consumption biomarkers and the risk of developing knee osteoarthritis. The project aims to use advanced metabolomic techniques to identify alcohol-related metabolites that predict the future incidence of...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $456,808 to the Buck Institute for Research on Aging to develop innovative mass spectrometry imaging (MSI) technologies and perform deep proteomic profiling of bone tissues. The goal is to spatially visualize changes in the extracellular matrix and glycans related to osteoarthritis,...
This Project Grant award, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop computational tools to accurately predict and interpret different patterns of knee pain in patients with osteoarthritis. The $348,680 award, with a period of performance from Sep 26, 2024 to Aug 31, 2026, will enable researchers at the University of Arizona to: 1) Adapt a...
The National Institute on Aging (NIA) awarded a $639,997 Project Grant (CFDA 93.866 - Aging Research) to The Spaulding Rehabilitation Hospital Corporation to investigate how exercise regulates molecular circuitry in cartilage and the knee joint to promote cartilage integrity and joint health in the context of knee osteoarthritis. The 5-year project aims to provide mechanistic insights into how molecular cargoes in circulating extracellular vesicles impact osteoarthritic knee joint health in a...
This Project Grant award of $578,275.00 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports research by The Spaulding Rehabilitation Hospital Corporation in Charlestown, MA to investigate sex and age-related differences in the development of knee osteoarthritis. The research aims to mechanistically interrogate the direct role of soluble microenvironmental factors and extracellular matrix stiffening on the loss of cartilage integrity, using...