Project Grant K23AG088498
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,126,515 to Trustees of Indiana University in Indianapolis, IN to conduct research aimed at understanding how the L-BAIBA/FGF23 axis, an interaction between muscle and bone, can be targeted to enhance musculoskeletal health and resilience in aging populations. The research seeks to elucidate the mechanisms by which this muscle-bone signaling pathway becomes dysregulated with age, leading to...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $245,434 to Wake Forest University Health Sciences to conduct research on preserving muscle and bone health in older adults undergoing weight loss interventions. The 2.5-year project aims to develop automated analysis techniques to measure changes in muscle quantity and quality, as well as bone strength, using computed tomography (CT) scans collected as part of an ongoing clinical trial....
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $688,634.00 in funding to The Hospital For Special Surgery Fund, Inc. (dba HSS Foundation) from December 1, 2024 to November 30, 2029. The award supports research to investigate the mechanisms by which the constitutive type-I interferon (IFN-I) response suppresses osteoblastogenesis and bone formation, especially in the context of inflammatory conditions like rheumatoid...
- This $146,070 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate how the accumulation of senescent cells and their secretory phenotypes impact osteocyte mechanobiology in a 3D bone-mimicking microenvironment. The goals are to: (1) acquire experimental skills and career training to expand the researcher's program into cellular aging/senescence and molecular biology; (2) investigate how local vs. systemic senescent cells and...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to comparatively assess the therapeutic potential of combined anabolic therapy versus the current standard-of-care single-drug approach in postmenopausal women at high risk of fragility fracture. The $1,175,680 award, with a performance period from September 2024 to August 2027, will be used by...
- The National Institute on Aging (NIA) awarded a $354,000 Project Grant under the Aging Research program (CFDA 93.866) to Panorama Research Incorporated, a for-profit biotech company in Sunnyvale, CA. The grant supports research to develop a novel therapy for sarcopenia, characterized by age-related loss of skeletal muscle mass, quality, and strength. The proposed therapy is based on the adipokine Isthmin 1 (ISM1), which has been shown to promote protein synthesis and suppress degradation...
- This $1,610,219 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846), will fund a 5-year longitudinal study examining the relationship between muscle quantity, quality, function, and biomarkers with changes in bone density, microarchitecture, and strength in older adults. The University of Pittsburgh will conduct this research, which aims to...
- This $644,864 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports preclinical studies by Ridgeline Therapeutics LLC, a Houston-based biotech company, to evaluate the efficacy of their lead compound RT-002 in preventing and reversing disuse-induced muscle atrophy in aging rat models. Specifically, the project aims to determine if RT-002 treatment can mitigate the loss of muscle mass and strength during muscle disuse, as well as improve the rate...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $166,488 Project Grant to the University of California, Davis to investigate the role of hypoxia-inducible factor-2a (HIF-2a) signaling in age-induced bone loss. The project aims to identify mechanisms underlying bone deterioration with aging and develop novel therapies to reverse age-related osteoporotic bone loss and improve fracture resistance. The project period runs from December...
- This National Institutes of Health National Institute on Aging project grant awarded $105,176 to Augusta University Research Institute, Inc. to support research directed at understanding the potential link between aging-related decreases in bone mass and kidney function. Specifically, the award will fund investigation of how increased levels of the metabolite kynurenine may induce an aged phenotype resulting in both bone loss and kidney dysfunction through the FGF23/klotho pathway. The...
This Project Grant award, titled "IMPACT OF DIFFERENT CLASSES OF OSTEOPOROSIS MEDICATIONS ON MUSCLE HEALTH IN OLDER ADULTS", was provided by the National Institute on Aging under the Aging Research federal grant program (CFDA 93.866). The $162,020 award, granted on August 5, 2025, will support the career development of geriatrician and endocrinologist Dr. Nami Safai Haeri. The key objectives of the research are to: 1) evaluate the impact of different osteoporosis medication classes on skeletal muscle health in older adults in long-term care facilities, 2) explore associations between bone quality and muscle health, and 3) examine the relationship between muscle mass and bone metabolism markers. This research aims to enhance the therapeutic approach to the geriatric musculoskeletal condition of osteosarcopenia, which involves the coexistence of osteoporosis and sarcopenia, in a population at high risk of fractures, falls, and poor health outcomes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $162.0k | 8/4/25 |