Project Grant K23AA033416
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded Massachusetts General Hospital a $735,930 Project Grant (R34) on September 23, 2025, under the Alcohol Research Programs (CFDA 93.273) to develop, validate, and conduct an open trial of a large language model (LLM)-based conversational agent for delivering brief alcohol interventions to emerging adults ages 18-29. The project, which runs through August 31, 2028, addresses the critical public health need to expand screening...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Leland Stanford Junior University $588,650 on July 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct a pragmatic three-arm randomized controlled trial evaluating digital interventions for alcohol use in emergency department settings. The trial will enroll 750 adult ED patients with risky alcohol use and randomize them to standard care, a conversational AI agent (MICA) delivering motivational...
- The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $576,197 on September 16, 2025, under the Alcohol Research Programs (CFDA 93.273) to develop and test a digital pill system paired with smartphone-delivered cognitive behavioral therapy to measure and support acamprosate adherence in individuals with alcohol use disorder and alcohol-associated liver disease. Yale will develop a user-centered adherence intervention called ACAMPROSYNC that combines a digital pill system...
- The National Institute on Alcohol Abuse and Alcoholism awarded Brown University $628,846 on September 25, 2025, under the Alcohol Research Programs (CFDA 93.273) to develop and evaluate virtual reality interventions that immerse patients with alcohol use disorder in realistic high-risk situations to help them identify triggers, experiment with coping strategies, and practice deploying those strategies in simulated environments. The project addresses a treatment gap: only about one-third of...
- The National Institute on Alcohol Abuse and Alcoholism awarded Behavior Change Hub LLC $303,008 on July 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to develop a didactic and interactive simulation training product targeting provider knowledge and skill in alcohol misuse and alcohol use disorder treatment. The training suite, called the Behavioral Health Counseling Competencies AUD Training Suite, integrates NIAAA's Rethinking Drinking dissemination resource with four core...
- The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $671,854 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct neurocomputational and ecological assessments of the mutual influence between alcohol craving and decision-making. The research examines the bidirectional interactions between alcohol craving and maladaptive decision-making in heavy and binge drinkers, with the goal of developing computational models that account for the...
- The National Institute on Alcohol Abuse and Alcoholism awarded Here & Now Systems LLC $306,746 on July 1, 2026, to develop an enhanced version of the STEP AWAY Alcohol Manager (SAAM), a mobile health intervention for alcohol use disorder treatment, under the Alcohol Research Programs (CFDA 93.273). SAAM is a mobile application that delivers personalized alcohol intervention through integration of artificial intelligence and biometric monitoring. The Phase I project incorporates multi-agent...
- The National Institute on Alcohol Abuse and Alcoholism awarded the Regents of the University of Michigan $2,105,899 on September 15, 2025, under the Alcohol Research Programs (CFDA 93.273) to conduct a fully-powered randomized controlled trial testing the efficacy of a social-media-based intervention for high-intensity drinking among emerging adults. The intervention delivers eight weeks of motivational interviewing-based content through private social media 1:1 messaging with health coaches,...
- The National Institute on Alcohol Abuse and Alcoholism awarded Washington State University $498,203 under the Alcohol Research Programs (CFDA 93.273) on August 1, 2026, to develop a just-in-time adaptive music-listening mobile health intervention for stress reduction among individuals in early recovery from alcohol use disorder. The research aims to create the first music-listening intervention leveraging passive sensing and machine learning to automatically predict and respond to moments of...
- The National Institute on Alcohol Abuse and Alcoholism awarded New York University School of Medicine $2.920164 million on August 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to develop and evaluate a precision prevention approach for identifying and addressing behavioral health treatment gaps that drive suicide risk. The project will identify subgroups at highest risk of suicidal thoughts and behaviors, characterize which combinations of mental and substance use disorders place...
The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $182,183 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to develop artificial intelligence agents that generate personalized, multimedia cognitive behavioral therapy content for alcohol use disorder treatment, targeting English speakers and Spanish speakers. The project will create AI-generated CBT content delivered via smartphone to address high-risk drinking periods, such as weekends. The intervention builds on the evidence base of existing programs like CBT4CBT-A, which has demonstrated efficacy in three randomized clinical trials including a trial with Spanish-speaking patients. Unlike conventional digital interventions, the AI approach enables rapid generation of context-specific content matched to patient language preference and environment, designed to improve engagement and treatment access for populations facing cost, stigma, logistical, linguistic, and cultural barriers to traditional AUD care. Work is performed in New Haven, Connecticut, with a period of performance from September 1, 2026, through August 31, 2031. The award is structured as a Project Grant, the standard assistance type under NIAAA's research portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $182.2k | 8/31/26 |