Project Grant K22CA293300
- This $150,104 Project Grant award from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) supports research to understand the evolutionary trajectories of complex genomic rearrangements in cancer. The project aims to develop novel computational approaches, "AGAVE" and "ROSE", to characterize the timing and dynamics of focal amplifications and structural variants during tumor evolution. The research will map these evolutionary patterns across...
- This $292,028 Project Grant awarded by the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) supports research to investigate the mechanisms by which oncogene amplification leads to genome instability and the development of therapy-resistant cancer clones. The research will be conducted by the Sloan-Kettering Institute for Cancer Research in New York and is scheduled to run from August 1, 2025 to July 31, 2030. Using single-cell genomic sequencing techniques, the project aims...
- This $119,922 federal Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) supports research by The University of Texas Southwestern Medical Center, doing business as Southwestern Medical School, to dissect the role of the Fanconi Anemia (FA) pathway in driving chromothripsis, a complex chromosomal abnormality observed in approximately 30% of cancer genomes. The research aims to elucidate the underlying mechanisms by which the FA genome maintenance...
- This $1,449,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to study the fundamental regulation of extrachromosomal DNA (ecDNA) in cancer genomes. The project aims to develop new live-cell chromatin labeling strategies and integrate advanced imaging, synthetic genome engineering, and optical/genetic perturbation to systematically investigate how ecDNA orchestrates massive...
- This federal Project Grant award from the National Cancer Institute (NCI) under CFDA 93.396 (Cancer Biology Research) provides $182,755 to Cold Spring Harbor Laboratory (CSHL) to conduct research on genetic technology development for understanding lineage plasticity mechanisms in cancer. The award began on August 21, 2025 and is scheduled for completion on July 31, 2030. The key products and services to be delivered through this grant include: 1) developing a CRISPR screening methodology for...
- This $204,027 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) is supporting the Weill Medical College of Cornell University in expanding single-cell and spatial technologies to link clonal genotypes with phenotypes during cancer evolution. The grant aims to develop advanced single-cell methods that can capture multiple data modalities, including genotypes, transcriptomes, methylomes, and protein expression, to better understand how somatic...
- This $150,104 federal Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) to Yale University supports research to determine the regulatory role of dose-sensitive 5-methylcytosine (m5C) modifications on mRNA translation initiation and their impact on cancer. The project aims to screen approximately 35,000 human 5' untranslated regions (5'-UTRs) for m5C installation by the methyltransferases NSUN2 and NSUN6, and quantify ribosome recruitment to these...
- This federal Project Grant award, valued at $401,829.00 and awarded by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), supports innovative research by Weill Medical College of Cornell University to develop transformative methods for high-throughput single-cell mapping of DNA-binding proteins. The project, titled "Precision Single-Cell Mapping of Chromatin-Associated Protein Activity by Molecular Footprinting to Chart Disruptions to Gene Regulation...
- This $147,486 Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) supports research by Baylor College of Medicine to investigate the role of the HP1BP3 protein in regulating chromatin remodeling and its impact on tumor growth in high-grade glioma, the most common malignant adult brain cancer. The research aims to define epigenomic dysregulations that promote glioma growth and determine the mechanisms by which these alterations drive tumorigenesis....
- This federal Project Grant award of $134,757.00, provided by the National Cancer Institute under the Cancer Research Manpower (CFDA 93.398) program, supports research to identify therapeutic vulnerabilities of chromosome 3 rearranged myeloid leukemias. The overall objective is to develop and apply novel proteogenomic approaches to study these aggressive blood cancers, which currently lack targeted precision therapies and have dismal 5-year survival rates. The award will fund research...
This federal Project Grant award of $194,914 from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) supports research to investigate the role of trans-acting factors and cis-element sequences in activating oncogenes in rearranged human genomes. The awardee, the University of Texas Health Science Center at Houston, will employ CRISPR/Cas9 genome engineering to introduce chromosomal translocations near oncogenes and model their expression using single-cell multi-omic sequencing data (Aim 1). The project aims to systematically identify transcription factors and co-activators specific to certain oncogene rearrangements and assess their impact on quantitative oncogene expression modeling. The award has an ultimate completion date of August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $194.9k | 9/12/25 |