Project Grant K22AI186623
- The University of Chicago was awarded a $295,276 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), to computationally investigate key morphological transitions in the HIV-1 life cycle. The research aims to develop a mechanistic understanding of viral assembly, maturation, and uncoating processes, which could aid in the design of new antiretroviral therapies targeting...
- This Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $714,754 to Northwestern University from November 2024 to October 2029 to conduct research on the role of FEZ protein homologs in early HIV-1 infection. The research aims to develop a detailed structural and functional understanding of how FEZ family members interact with and impact HIV-1 infection, which could guide...
- This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the dynamics and evolution of HIV Gag and GagPol processing. The $752,745 award aims to use molecular dynamics simulations, single-molecule FRET imaging, and cryo-electron tomography to probe the structure and dynamics of Gag and GagPol that enable ordered processing by the viral...
- This $624,902 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to investigate the impact of the HIV accessory protein Vpr on epigenetic remodeling and viral persistence in myeloid cells. The 5-year project, starting on Apr 23, 2025, will focus on characterizing how Vpr induces epigenetic changes to facilitate sustained HIV transcription and latency reactivation, as well as...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $859,992 Project Grant to Yale University for the "Molecular Investigations of HIV-1 Maturation Pathways and Inhibitor Actions in situ" research project. The grant, funded under NIAID's Allergy and Infectious Diseases Research Program (CFDA 93.855), aims to use advanced in-situ cryo-electron microscopy and tomography techniques to visualize the structural transitions of the HIV-1 virus during the maturation...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), awarded a $653,693 Project Grant to Emory University to conduct structural investigations of the HIV-1 virion and the mechanism of the capsid targeting compound lenacapavir. The research aims to leverage advanced cryo-electron microscopy and tomography techniques to study the structural details of immature HIV-1 assembly and the mechanistic...
- This federal Project Grant award of $848,839 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to uncover new mechanisms by which HIV accessory proteins control natural killer (NK) cell function. The research aims to identify new NK cell ligands regulated by HIV infection and examine how changes to HIV accessory proteins like Nef and Vif impact the "missing self" trigger that drives NK cell...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $240,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Northwestern University to conduct research on characterizing the HIV-1 viral reservoirs that persist even under antiretroviral therapy (ART). The 2-year project aims to identify the cellular sources and genetic diversity of the HIV-1 reservoirs, as well as study the sources and characteristics of the residual viremia...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $1,505,785 Project Grant to Northwestern University to support the HIV Implementation Science Coordination Initiative (ISCI). The grant, awarded on Sep 3, 2025, with a completion date of Aug 31, 2030, aims to: 1) Integrate implementation and effectiveness data across NIAID's Ending the HIV Epidemic (EHE)-funded projects to create...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $617,376 to Emory University to conduct research on the activation and maturation of the HIV-1 virus. The key objectives are to: 1) Measure the timing of protease (PR) activation relative to HIV-1 budding from the host cell, 2) Assess the rate and extent of PR substrate cleavage and correlate this with formation of...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) provides $156,160 to Northwestern University to study the structural basis of HIV accessory proteins VPR and VIF. The goal is to contribute to understanding and potentially combating the HIV/AIDS pandemic through structural biology research. The award period runs from September 1, 2025 to August 31, 2027. The project aims to leverage recent advancements in cryogenic electron microscopy to analyze the interactions between HIV accessory proteins and host factors, which play critical roles in virus infectivity and immune evasion. This research seeks to provide atomic-level insights into these challenging protein complexes, advancing knowledge to support future rational drug design efforts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $156.2k | 8/26/25 |