Project Grant K22AI177360
- This $247,236 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to the Regents of the University of Minnesota, Office of Sponsored Projects Administration. The purpose of this 3-year award, with a period of performance from Dec 10, 2024 to Jul 31, 2027, is to conduct research to determine the key factors of inflammation that support the expansion and function of...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to define the immunological mechanisms and functional potential of memory-phenotype CD8+ T cells in the context of infection and cancer. The $108,512 award, made on August 25, 2025, will enable researchers at the University of Chicago to investigate how these CD8+ T cells differentiate and acquire unique...
- The federal Project Grant award of $3,436,588.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The award supports research to investigate the role of the TLE3 transcription cofactor in regulating the function and persistence of CD8+ T cells during chronic viral infections and cancer. The research aims to molecularly reconstruct the T cell exhaustion process and identify therapeutic...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $639,084 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to Children's Hospital Medical Center in Cincinnati, Ohio. The grant supports research to elucidate the functional heterogeneity of naive CD8 T cells, the precursors of effector and memory T cells that are critical for immune responses against pathogens and cancer. The 5-year project aims to provide a deeper understanding of...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $462,000 Project Grant under the Allergy and Infectious Diseases Research Program (CFDA 93.855) to Albert Einstein College of Medicine in the Bronx, NY. The grant, awarded on July 7, 2025, supports research to design improved T cell epitopes for enhancing the effectiveness of T cell vaccines and therapies, with a focus on generating stem-cell-like memory T cells. The research aims to define and validate the molecular and...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), CFDA 93.855 Allergy and Infectious Diseases Research program, supports research to investigate the role of Ly49 receptors on CD8 T cells. The $649,053 award to The Washington University in Missouri aims to better understand the functional contribution of Ly49 receptors and the transcription factor Helios to the development and function of CD8 regulatory T cells (Tregs). This research seeks to...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $107,995 to investigate the role of T cells in promoting post-acute memory deficits after COVID-19 infection in mice. The funding supports the use of a recently developed mouse model to study how systemic inflammation promotes the recruitment of antigen-specific T cells to the central nervous system after SARS-CoV-2 infection, and how these T...
- This Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), to support research on the cell-specific roles of CD153 and CD30 in regulating immune responses, particularly in the context of aging and immune function. The $441,375 award covers the period from Aug 1, 2025 to Jul 31, 2027 and was granted to the Children's Hospital Medical Center in Cincinnati,...
- This $534,000 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the role of antigen location, peptide:MHCII complex density, and complex half-life as drivers of CD4+ T cell differentiation. The research, conducted by the Children's Hospital of Philadelphia, aims to provide clarity on how the strength of "Signal 1" (antigen...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) in the amount of $107,919 supports research to elucidate the mechanisms by which the transcription factors S1PR and KLF regulate CD8+ T cell trafficking and differentiation. The research aims to explore the role of S1PR-independent KLF2-regulated pathways in CD8+ T cell migration and memory formation (Aim 1), as well as the influence of KLF2 in...
This $162,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), supports research to investigate the mechanisms that maintain the longevity and functional diversity of memory CD8+ T cells in both circulating and tissue-resident populations. The research aims to elucidate how these memory T cell subsets are regulated by cytokines during homeostasis and in response to infection or other physiological perturbations. The findings could inform the development of immunotherapies to expand memory CD8+ T cell populations, with potential applications in vaccination and cancer treatment. The award was granted to Versiti Wisconsin, Inc., a non-profit blood center and research organization in Milwaukee, Wisconsin, and the project is set to be completed by July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $162.0k | 8/12/25 |