This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate how dysfunction in the cerebellar nuclei contributes to the motor deficits observed in Spinocerebellar Ataxia Type 1 (SCA1). The $423,500.00 award to the Regents of the University of Minnesota will fund a 2-year project to determine how the...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $454,999 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to the Regents of the University of Minnesota. The grant aims to determine how mutant ataxin 1 (mATXN1) affects the function of cerebellar astrocytes and how astrocyte dysfunctions contribute to the onset and progression of Spinocerebellar Ataxia Type 1 (SCA1), a fatal...
This Project Grant award of $605,523 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research to investigate the role of Purkinje cell synaptic changes in cerebellar degeneration and identify potential therapeutic approaches. The research aims to determine how the loss of climbing fiber-Purkinje cell synapses differentially contributes...
The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services, awarded a $4,528,840 Project Grant to The Salk Institute For Biological Studies under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The three-year award beginning August 19, 2022 will fund research to functionally dissect cerebellar output circuits that orchestrate limb motor control. Specifically, the grantee will...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $509,145 project grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The University of Texas Southwestern Medical Center to support research on understanding the degeneration of neurons in the inferior olivary nucleus. The research aims to investigate the shared molecular mechanisms underlying different triggers for olivary neuron degeneration, which is...
This $1,504,638 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to understand the role of the per-arnt-sim domain kinase (PASK) in regulating autophagy and the nutrient-sensing kinases mTOR and AMPK in the context of spinocerebellar ataxia type 2 (SCA2), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,133,250 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to Weill Medical College of Cornell University. The 5-year grant, awarded on September 18, 2024, supports research to identify and mechanistically explain motor superperformance mutations, using a mouse model, that could elucidate novel neural mechanisms underlying motor...
This federal Project Grant award for $2,307,075.00, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports innovative research aimed at defining novel mechanisms of neurodegenerative diseases and devising potential therapeutic strategies. The primary recipient, The Leland Stanford Junior University, will conduct genome-wide modifier screens in human...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $503,439.00 to support research on the functional roles of inhibitory cerebellar outputs. The research aims to advance the understanding of cerebellar learning mechanisms and their impact on feedforward motor control. Specifically, the project will investigate how the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,282,359.00 to the Regents of the University of Michigan to conduct research on the regulation of intermediate progenitor cells during neural development. The project aims to define the mechanisms that control the competency of neural stem cells to generate intermediate...