The Trustees of Columbia University in the City of New York has been awarded a $605,523 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award will fund research to investigate the relationship between the loss of specific synaptic connections in the cerebellum and the development of ataxia symptoms in a mouse model of cerebellar degeneration. The research aims to determine if interventions to enhance or restore these synaptic connections can improve cerebellar circuit function and alleviate ataxia symptoms, particularly in the early versus late stages of degeneration. The study will also examine whether changes in the cerebellar alpha rhythm can serve as a biomarker to track disease progression and therapeutic responses. The knowledge gained from this research is intended to inform the development of disease-stage-specific therapies to restore circuit function in cerebellar degeneration.
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