Project Grant K08HL177173
- The National Heart, Lung, and Blood Institute (NHLBI) has awarded a $2,442,173 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Leland Stanford Junior University (Stanford University) to identify genes and pathways that influence the risk of vascular diseases such as coronary artery disease (CAD) and pulmonary arterial hypertension (PAH). The 5-year award, effective August 15, 2025, will leverage innovative CRISPR genomics approaches to characterize gene...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $410,449 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program to The Leland Stanford Junior University (Stanford University) on August 1, 2025. The funding supports research to develop novel synthetic biology strategies that would enable the quantitative and dynamic regulation of growth factors and cytokines produced from human induced pluripotent stem cell-derived endothelial cells (iPSC-ECs). The goal...
- This Project Grant award of $705,405 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to The Leland Stanford Junior University supports research focused on characterizing the role of adventitial fibroblasts in atherosclerosis. The research aims to identify new therapeutic targets and pathways related to this understudied cell population's influence on atherosclerotic plaque formation and calcification. The project will leverage single-cell genomics,...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research provides $768,198 to the Augusta University Research Institute, Inc. (dba Georgia Health Sciences) to conduct research on the function and transcriptional regulation of the Leiomodin1 (LMOD1) gene, which is associated with coronary artery disease (CAD). The research aims to elucidate the role of LMOD1 in maintaining normal vascular smooth muscle cell function...
- The National Heart Lung and Blood Institute (NHLBI), a civilian agency within the U.S. government, awarded a $683,048 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Research Institute at Nationwide Children's Hospital. The purpose of this 5-year project grant, with a start date of May 1, 2025 and a completion date of March 31, 2030, is to investigate the cellular and molecular mechanisms by which the zinc ion importer ZIP8 impacts the formation of the...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is providing $331,344.00 to The Leland Stanford Junior University to investigate the gene regulatory mechanisms of the coronary artery disease gene PRDM16 and its impact on smooth muscle cell phenotypic modulation. The research aims to determine how PRDM16, an epigenetic modifier, regulates the transition of smooth muscle cells into protective "fibromyocytes"...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $243,000 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Cincinnati's Sponsored Research Services Division. The grant will fund a 2-year project to engineer advanced RNA biodevices that leverage CRISPR and ADAR gene-editing technologies. The goal is to improve the efficiency and specificity of converting resident cardiac fibroblasts into functional cardiomyocytes, in order to boost...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $540,856 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Regents of the University of California, San Francisco (UCSF) on Dec 15, 2024. The goal of this 4-year project is to identify transcriptional regulators that control endocardial-specific gene expression and valve development, as well as understand the regulation and function of the SLC16A2 gene during heart injury and regeneration. The...
- The National Institutes of Health's National Heart, Lung, and Blood Institute awarded a $630,169 Project Grant on August 20, 2025 to Cedars-Sinai Medical Center for the federal Cardiovascular Diseases Research program (CFDA 93.837). The funding supports a research project titled "Nuclear Transport of Developmental Signaling Effectors" that aims to investigate the mechanism by which key signaling proteins (Smads) enter the cell nucleus to regulate gene transcription and embryonic...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $775,720 project grant to Yale University under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) to conduct research on the role of endothelial protocadherins in vascular development and disease. The project aims to: 1) determine the effects of knocking out or inhibiting the protocadherin gamma (PCDHG) cluster in endothelial cells in mouse models of vascular inflammation, 2) elucidate the mechanism by which...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a 5-year, $165,888 Project Grant to The Leland Stanford Junior University (Stanford University) to conduct research on the role of the ZEB1 transcription factor in the development of coronary artery disease (CAD). The primary objective is to characterize and establish the causal role of ZEB1 in atherosclerosis development. The research will use a ZEB1 knockout mouse model to determine the transcriptional, epigenetic, and plaque phenotype of smooth muscle cells. Functional genomics and proteomics will also be employed to elucidate the mechanisms by which ZEB1 influences CAD risk. This grant, funded through the Cardiovascular Diseases Research program (CFDA 93.837), aims to advance scientific understanding of genetic risk factors and disease mechanisms underlying the leading cause of death worldwide.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $165.9k | 8/21/25 |