Project Grant K08HL177154
- The Project Grant award of $759,658 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at The General Hospital Corporation (doing business as Massachusetts General Hospital) to develop and validate a mechanomicroscopy imaging platform for the transbronchial assessment of pulmonary artery pressure and arterial smooth muscle thickening in patients with pulmonary hypertension due to lung disease. The key products and services to be...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $170,640 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), on August 15, 2025. The grant supports research by Dr. Tristan Kooistra, a physician-scientist at MGH and Harvard Medical School, to investigate how epithelial-derived Notch signals promote the maturation of airway macrophages and influence allergic...
- This $453,750 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), as part of the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), with an award date of June 17, 2025 and an ultimate completion date of May 31, 2027. The grant supports research to define novel mechanisms of communication between airway epithelial cells and intraepithelial airway macrophages, using an innovative high-throughput airway organoid screening...
- The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $1,127,798 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). This 7-year grant, effective February 1, 2025, will support research to understand the role of macrophages in preserving cardiovascular health, illuminating their contributions to cardiovascular disease, and...
- The federal Project Grant award of $108,978.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the mechanisms underlying the age-related decline in the regenerative capacity of alveolar type 2 (AT2) cells in the lung. The principal investigator and research team at the Harvard T.H. Chan School of Public Health will conduct studies to determine whether elevated interferon gamma (IFNG) levels and changes in resident...
- This $165,353 Project Grant was awarded on September 25, 2025 by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The grant funding will support research to define the association between severe obesity and regional lung perfusion, as well as test the effect of severe obesity on pulmonary vasoreactivity in patients with acute hypoxemic respiratory failure....
- The federal Project Grant award, titled "MicroRNAs in Airway Smooth Muscle Function and Asthma," was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The $616,814 award, with a start date of January 15, 2025 and a completion date of November 30, 2028, supports research at the President and Fellows of Harvard College (Harvard T.H. Chan School of Public Health) to investigate the role of microRNAs in regulating...
- This federal Project Grant award, worth $809,162.00, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to The Children's Hospital Corporation, doing business as Boston Children's Hospital, located in Massachusetts. The funding supports research to elucidate the differentiation pathways and functions of pulmonary ionocytes, a rare cell type in the human airway that expresses high levels of the cystic fibrosis transmembrane...
- This $229,608 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research investigating the role of pleural mesothelial cells in lung injury, repair, and regeneration. The award to Mayo Clinic aims to conduct lineage-tracing experiments in mouse models of lung injury and regeneration, and subsequent genomic analysis of the collected pleural mesothelial cells. This research seeks to improve the understanding of repair...
- This Project Grant award of $762,867.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to investigate the role of the cofilin-1 protein in regulating mitochondrial function and quality control in airway epithelial cells. The research, conducted by The Johns Hopkins University, seeks to understand how the loss of cofilin-1 impacts mitochondrial dynamics and mitophagy, and how these processes contribute to airway epithelial dysfunction in...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $170,640 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct research on the role of the airway hillock cell type in airway barrier function and regeneration. The award period runs from September 15, 2025 to August 31, 2030. The research aims to define the mechanisms by which the hillock cell resists injury and promotes the restoration of mucociliary transport in the airway. Specific objectives include characterizing the molecular mechanisms underlying the hillock cell's barrier function and its ability to differentiate into ciliated cells to regenerate the airway epithelial surface. This grant supports cutting-edge translational research that could lead to improved understanding and treatment of respiratory diseases like asthma, COPD, and bronchiectasis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $170.6k | 9/15/25 |