The National Heart, Lung, and Blood Institute (NHLBI) awarded a $528,179 Project Grant (CFDA 93.837 Cardiovascular Diseases Research) to the University of Miami to investigate novel strategies for improving neovascularization and limb perfusion in peripheral arterial disease and critical limb ischemia. The research aims to determine if extracellular vesicles mediate a systemic effect that reprograms bone marrow-derived monocytes, and whether modulating the DHCR24 enzyme in myeloid cells can...
This $500,089.80 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support research to investigate the role of inflammatory macrophages in cardiac remodeling and diastolic dysfunction associated with heart failure with preserved ejection fraction (HFPEF). The research aims to uncover the molecular, cellular, and functional mechanisms by which macrophages mediate fibroblast differentiation...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), provides $687,517 to the University of Alabama at Birmingham (UAB) to elucidate the role of the gene Leiomodin1 (LMOD1) in the formation of mature blood vessels, which is critical for regulating the pathogenesis of peripheral artery disease (PAD). The project aims to use cell culture models, genomic approaches, and mouse models to...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $230,684 to The Trustees of the University of Pennsylvania to conduct research on the role of endothelin receptor-B (EDNRB) in perivascular macrophages. The key objectives of this 2.7-year project are to: 1) assess the iron content and transcriptional profile of perivascular macrophages in adipose tissue using single-cell RNA...
This $1,659,996.00 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Southern California (USC) to investigate the role of the PDLIM2 protein in alveolar macrophage function and its impact on lung immunity, inflammation, and disease. The research aims to determine how PDLIM2 regulates the phagocytic and immune regulatory capabilities of alveolar macrophages, and how its repression promotes...
The National Institutes of Health National Heart Lung and Blood Institute awarded a $511,680 Project Grant to the University of Illinois under the Cardiovascular Diseases Research program (CFDA 93.837). The grant will fund research from February 2021 through August 2021 to investigate mechanisms by which vascular endothelial cells instruct macrophage fate in inflammatory injury. Specifically, the research will examine how endothelial cell Wnt signaling licenses the differentiation of monocytes...
The federal Project Grant award R03HL172985, totaling $131,485, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The award supports research to understand proline dysregulation in pulmonary artery endothelial cells, with a focus on the role of C-terminal Src kinase (CSK) and Src-dependent regulation of proline metabolism in early-stage pulmonary arterial hypertension (PAH). The research aims to...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $1,127,798 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct research on the role of macrophages in cardiovascular health and disease. The key objectives are to: 1) understand how macrophages influence cardiovascular health, 2) elucidate macrophage contributions to cardiovascular disease,...
The federal Project Grant award of $583,233 was made by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program. The grant will fund research at The Washington University in Missouri to investigate the role of circulating osteopontin and CD44 receptors on innate immune cells in driving remote lung inflammation following acute kidney injury. The key objectives are to: 1) determine which osteopontin domains and cleavage are required...
This Project Grant award for $691,708.00 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program supports the development of a novel contrast-free ultrasound-based quantitative angio flow imaging technique to assess peripheral arterial disease (PAD) of the lower limbs. The research project aims to determine the efficacy of this new "Angio Flow Reactivity Analysis" (AFRA) method for assessing PAD in patient...