This federal Project Grant award of $172,248 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support Dr. Muriel Babey's research to determine the role of brain-derived CCN3 in bone and marrow fat metabolism. The project aims to 1) elucidate how the dose and levels of circulating brain-derived CCN3 affect bone formation, and 2) delineate the role of circulating CCN3 on bone and marrow fat metabolism during aging, menopause, and high-fat diet challenges. This work will provide evidence to further develop CCN3 as a potential therapeutic approach for mitigating osteoporosis and fracture risk. The award will also facilitate Dr. Babey's career development, including training in specialized research techniques and skills needed for an independent academic research career.