Project Grant K08CA296776

Award Date 6/1/25
Completion Date 5/31/30
Dollars Obligated $139K
Federal Grant Program
93.398
Assistance Type
Project Grant
Place of Performance
Texas, USA
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The key objectives of the 5-year research project are to: 1) mechanistically examine how ecdna detection in antigen-presenting cells triggers anti-tumor signaling pathways; 2) evaluate how phagolysosomal release of ecdna stimulates innate and adaptive immune responses; and 3) assess the anti-tumor effects of an antibody-drug conjugate (CD47-LLO) in combination with frontline therapies in animal models of glioma and colorectal cancer with high ecdna expression. If successful, this research could support the development of an immunostimulatory therapy with potential to treat diverse cancers that rely on ecdna for survival.

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