This K08 Career Development Award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $210,973 in funding to Brigham and Women's Hospital over the period of September 1, 2024 to August 31, 2029. The award supports a research plan and career development program for Dr. Filipe de Carvalho, a urologic oncologist surgeon-scientist, to become proficient in tumor-associated macrophage biology in bladder cancer. The goal is to develop novel macrophage-directed therapeutic strategies for bladder cancer patients. Dr. de Carvalho will be mentored by Drs. Eliezer Van Allen, Kent Mouw, and Elizabeth Mittendorf, who are leaders in bladder cancer genomics and cancer immunology. The research will focus on determining the mechanism and effectiveness of targeting tumor-associated macrophages to improve sensitivity of bladder cancer to combined cisplatin and immune checkpoint inhibition, as well as dissecting the tumor-macrophage crosstalk that mediates cisplatin resistance.
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