The National Cancer Institute (NCI) awarded a 5-year, $231,870 Project Grant under the Cancer Research Manpower (CFDA 93.398) program to The Washington University in St. Louis. The goal of this research project is to train the Principal Investigator to become an independent academic physician-scientist studying immune responses against lung cancer. The research will investigate how lung fibrosis impairs tumor immunity and limits the efficacy of immune checkpoint inhibitors, with the aim of developing novel immunotherapy strategies for non-small cell lung cancer patients. The project will leverage the expertise and resources at Washington University, with mentorship from Dr. David DeNardo, to conduct studies using genetically engineered mouse models. The research has the potential to improve understanding of the tumor microenvironment and lead to the development of more effective combination therapies for lung cancer.
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