Project Grant K08AR086318
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $124,308 to the Fred Hutchinson Cancer Center in Seattle, WA to investigate the role of human satellite II (HSATII) RNA in the pathogenesis of facioscapulohumeral muscular dystrophy (FSHD). The research aims to determine the composition of HSATII-derived ribonucleoprotein...
- This federal Project Grant award of $671,240 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research to develop enhanced dystrophin gene therapies for Duchenne muscular dystrophy (DMD). The University of Washington will conduct this research from January 2025 through December 2029. The project aims to design and test micro-, mini-, and full-length dystrophin gene...
- This Project Grant award from the National Center for Advancing Translational Sciences (NCATS), CFDA 93.350, provides $313,372.00 to D4Z4 Medicine, Inc. to develop a long-read sequencing-based molecular diagnostic assay for Facioscapulohumeral Muscular Dystrophy (FSHD). The project aims to standardize and validate the long-read sequencing assay, increase its capacity by adding target regions, and optimize a bioinformatics pipeline with a user-friendly interface for analyzing the sequencing data....
- This $190,137 Cooperative Agreement was awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The agreement aims to bridge the gap between genetic testing and patient care for muscular dystrophies and myopathies by defining the clinical relevance of genes and genetic sequence variants associated with these disorders. Key efforts include evaluating the clinical validity of...
- The University of Florida was awarded a $599,496 project grant by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The objective of this 5-year project, with a performance period from September 15, 2025 to August 31, 2030, is to evaluate the potential of magnetic resonance (MR) measures of bioenergetics and microvascular function to track disease progression and...
- This federal Project Grant award of $471,513 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research to investigate the mechanisms underlying neuromuscular diseases where glycosylation is disrupted. The University of Maine System, through its Research & Sponsored Program division, will use a zebrafish model to study how loss of the dolichylphosphate mannose...
- The National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded New York University School of Medicine $409,311.92 under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) from April 5, 2021 to January 25, 2022. The project grant funding supports research into the role of T follicular helper (TFH) cells in the pathogenesis of dermatomyositis, a severe inflammatory myopathy. Specifically, the award will fund studies to...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $439,791 Project Grant to The University of Texas Southwestern Medical Center on March 1, 2025 under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The grant supports research to investigate the molecular mechanisms of myoblast fusion, which is essential for skeletal muscle development and regeneration. The research aims to understand the cellular and...
- This Project Grant award of $522,714 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the role of stretch activation in mammalian skeletal muscle endurance. The research will focus on measuring the characteristics and mechanisms of stretch activation in mouse slow-twitch and fast-twitch muscle fibers, including determining the specific myosin...
- This federal Project Grant award of $1,476,000.00 was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) and is being performed by the University of Texas Southwestern Medical Center (UT Southwestern) in Dallas, TX. The award will fund research to investigate the role of membraneless cellular compartments, known as biomolecular condensates, in neuromuscular diseases and other age-related disorders. The project aims to develop new...
This federal Project Grant award of $175,500 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the role of alternative splicing in Facioscapulohumeral Muscular Dystrophy (FSHD). The research project, performed by The Washington University, has three key objectives: 1) Characterize the interactions between the transcription factor DUX4 and RNA in muscle cells to identify alternative splicing targets, 2) Explore how DUX4 regulates the alternative splicing of the TNNT1 gene, which is abnormally spliced in FSHD, and 3) Develop an RNA splicing biomarker for FSHD by identifying and validating splicing changes in patient-derived cell lines. This research is expected to uncover molecular mechanisms through which DUX4 disrupts splicing in FSHD, providing a foundation for future diagnostic and therapeutic strategies. The award period runs from September 1, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $175.5k | 8/29/25 |