Project Grant K08AI182483

This federal Project Grant award, with an ID of K08AI182483, is funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The total funding amount is $195,894.00 over the award period from August 6, 2024 to July 31, 2029.

The primary objective of this grant is to study the mechanisms contributing to T cell dysregulation in STAT3 gain-of-function syndrome, a primary immune regulatory disorder. The research will focus on understanding critical interactions between T and B cells, as well as the development, polarization, and function of these cells. The project will utilize a murine model of STAT3 gain-of-function syndrome and viral infection models to conduct immunophenotyping, transcriptional analysis, and assess the impact on antigen-specific responses and mucosal tolerance. Additionally, in vitro assays will be used to define the impact of STAT3 gain-of-function on T cell polarization in patients. The overall goal is to provide the candidate with the necessary skills and knowledge to become an independent physician-scientist and make significant contributions to the field of primary immune regulatory disorders.