This federal Project Grant award, valued at $226,253.00 and made by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how the host protein ADAM10 modulates the interaction between neutrophils and endothelial cells during Staphylococcus aureus infection. The research program utilizes transgenic mouse models, in vivo imaging, and microbiological tools to provide a...
This $453,900 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant is funding research to develop a genome editing platform using broadly functioning phage recombinases, which can be used to genetically manipulate a wide range of bacterial species, including clinically relevant pathogens. The goal is to enable direct investigation of the genetic elements driving bacterial...
This Project Grant award, valued at $231,700 and provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research), supports research to develop biologics that can block the agglutination of S. aureus bacteria with fibrin clots. The overall objective is to create novel therapeutic candidates for treating S. aureus infections, including antibiotic-resistant strains like MRSA. The research will 1) characterize the binding and...
This federal Project Grant award of $918,400 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports research at the University of Chicago to identify protective antigens and T/B cell responses against Staphylococcus aureus (S. aureus) infection. The goal is to exploit the observation that mice lacking the H2-O molecule, the equivalent of human HLA-DO, are able to efficiently decolonize S. aureus and resist subsequent...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $267,310 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Illinois in Chicago. The grant, titled "Evaluating the Role of a Lipoic Acid Transfer Protein in Staphylococcus aureus Metabolism and Virulence," aims to better understand how the S. aureus bacterium adapts its metabolism to survive and cause infection in the human body. The research will...
This Federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop a single-cell resolution understanding of pathogenesis and antibiotic tolerance in the bacterium Staphylococcus aureus. The $312,000 award, valid from September 1, 2024 to August 31, 2026, will be performed by the University of Texas Health Science Center at Houston. The key products and services to...
This $189,558 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify bacterial genomic factors associated with antibiotic treatment failure in Staphylococcus aureus bacteremia (SAB). The central hypothesis is that specific genomic changes in S. aureus enable evasion of the immune system and antibiotics, leading to worse clinical outcomes for patients. The...
This Project Grant award, with a total funding amount of $390,000.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant is focused on elucidating the molecular basis of how the bacterium Staphylococcus aureus uses its unique serine protease-like (Spl) enzymes, particularly the Spl-B enzyme, to manipulate host proteins and evade the immune system during infection. The research...
This $126,174 Federal Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to utilize a novel skin-on-a-chip model to investigate extramedullary granulopoiesis and immune responses in human skin, with the goal of providing insights into combating antibiotic-resistant skin infections. Specifically, the research aims to: 1) Demonstrate the HSPC signaling...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $147,656 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to St. Jude Children's Research Hospital Inc. The grant supports research to determine: 1) the specificity underlying mucin-mediated autolysis inhibition in Streptococcus pneumoniae; 2) the impact of mucin-mediated autolysis inhibition on pneumococcal cytotoxicity; and 3) the genetic determinants required for prolonged...