Project Grant K01MH141330
- The National Institute of Mental Health (NIMH) awarded a $206,250 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for the project "A COPY NUMBER VARIANT DISCOVERY PIPELINE FOR INTEGRATED GENOME-EXOME SEQUENCING". The award period runs from Sep 1, 2025 to Aug 31, 2027. The project aims to develop a pipeline to detect copy number variants (CNVs) across the genome and...
- This federal Project Grant award of $702,928 was provided by the National Institute of Mental Health (NIMH), which administers the Mental Health Research Grants program (CFDA 93.242), to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The grant supports research to enhance the integration of multi-organ imaging data of the brain and body, psychiatric genetic studies, and functional genomic data resources to uncover...
- This $129,290 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research at Massachusetts General Hospital (MGH) to analyze phenotypic, genetic, and neurobiological data from over 43,000 participants with autism spectrum disorder (ASD) and schizophrenia (SCZ). The goal is to better understand how genetic variation associated with intellectual disability, ASD, and SCZ maps onto developmental...
- This federal Project Grant award, valued at $453,750.00 and effective September 1, 2025, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research program led by The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to advance the understanding of perioperative neurocognitive disorders (PND) and their association with disruptions in...
- This Cooperative Agreement award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $7,013,600 in funding to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), from September 1, 2025 to August 31, 2029. The project, titled "SCALABLE PHENOTYPING TO ASSAY RISK IN CHILDHOOD AFTER EXPOSURES IN PREGNANCY: SPARC-XP", aims to generate risk models to predict neurodevelopmental...
- This Project Grant award from the Department of Health and Human Services' National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $380,103 to Drexel University to rapidly develop and evaluate precision psychiatry digital health interventions using dynamic systems modeling and ecological quasi-experiments. The project aims to improve the efficacy of digital mental health interventions by leveraging real-world, person-centered data to understand...
- This Project Grant award from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) will provide $600,000 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to purchase a next-generation 3 Tesla human MRI scanner for mental health research. The new MRI system will replace an obsolete 16-year-old scanner and integrate with MGH's existing PET-MRI facility at the Athinoula A. Martinos Center for Biomedical Imaging. The...
- This Project Grant award of $836,344 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to investigate the cellular and molecular factors underlying neuroprogression in early-course psychosis. The key objectives of this 5-year project are to identify the connections between neuroprogression, blood-brain barrier dysfunction, and...
- This federal Project Grant award, valued at $1,461,016.00, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant supports research to evaluate the effect of network-based real-time neurofeedback on mindfulness practice for reducing repetitive negative thinking in adolescents at risk for serious mental illness. The grantee, The General Hospital Corporation (dba Massachusetts General Hospital), will develop and...
- This federal Project Grant award of $182,851 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The goal of the 5-year research project is to identify deficient memory replay as a potentially treatable mechanism for the impaired sleep-dependent memory consolidation observed in individuals with schizophrenia. Cognitive deficits...
This Project Grant award, valued at $183,118, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The funded project, titled "Integrating Genomics and EHR to Accelerate Precision Psychiatry," aims to address key limitations in translating genomic findings to clinical practice in psychiatric disorders. The project will derive etiological insights into clinically-relevant psychiatric phenotypes and build translational models to predict these traits in large, diverse samples by integrating genomic data with electronic health record (EHR) information. Specific objectives include developing phenotyping algorithms, conducting multi-ancestry genome-wide association studies, and applying a superlearner framework to predict clinical course traits using polygenic scores and EHR-derived risk factors. This award, with a project period from Sep 1, 2025 to Aug 31, 2029, supports the advancement of precision psychiatry by addressing critical gaps in leveraging genomic and EHR data to improve patient stratification, risk prediction, and targeted treatment for mental health conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $183.1k | 8/18/25 |