Project Grant K01MH141314
- Federal Grant Award Summary Yale University received a $461,084 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded June 16, 2025, with completion targeted for June 15, 2027. The award funds research investigating the cellular and circuit mechanisms underlying age-dependent social behaviors, specifically examining how pro-opiomelanocortin (POMC) neurons in the hypothalamus regulate social interactions during...
- Federal Grant Award Summary Yale University received a $838,378 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to conduct fundamental neuroscience research on infant social behavior and learning. The award, effective March 10, 2026 through February 28, 2031, supports investigation of somatostatin-expressing neurons in the zona incerta (ZISST neurons) of infant mice and their role in modulating responses to...
- Federal Grant Award Summary Yale University received a $3.3M project grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded September 19, 2025, with completion scheduled for September 18, 2029. This research project investigates the prefrontal mechanisms underlying social interaction strategies by combining advanced methodologies including automated behavioral paradigms, video-based tracking of facial and body features,...
- Federal Grant Award Summary Yale University received a $839,329 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective May 1, 2026, with a completion date of February 28, 2031. The award funds the first in vivo human positron emission tomography (PET) imaging study investigating how menopause affects synaptic density in corticolimbic brain regions and whether major depressive disorder (MDD) exacerbates...
- Federal Project Grant Award Summary Yale University received a $847,792 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective July 1, 2026, through April 30, 2031. This award supports the development of integrated human thalamocortical assembloids—three-dimensional neural structures created through stem cell technologies—designed to produce thalamocortical oscillations that replicate human brain rhythms. The...
- Federal Grant Award Summary Yale University received a $121,842 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective April 1, 2026, through March 31, 2028. The award funds research investigating the neural mechanisms underlying altruistic decision-making, specifically examining how the medial prefrontal cortex (MPFC) and striatum interact to evaluate costs and rewards when individuals make decisions that...
- Summary of Federal Project Grant Award Yale University received a $665,494 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective September 1, 2025, through July 31, 2028. The award funds the development of a Social Interaction Suite (SIS)—an integrated system of synchronized neural and behavioral measurement tools designed to study cognitive processes during live face-to-face interactions. The SIS platform...
- Federal Grant Award Summary Award Details: The National Institute of Mental Health (NIMH) awarded Tufts University School of Medicine a Project Grant totaling $182,916 under the Mental Health Research Grants program (CFDA 93.242) on October 17, 2025, with an ultimate completion date of October 23, 2027. Research Scope and Deliverables: This project investigates cell type-specific mechanisms of glutamatergic synapse function and organization, with a focus on how the protein BTBD11 regulates...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of Pennsylvania a $2,693,038 Project Grant under the Mental Health Research Grants program (CFDA 93.242) for the period September 1, 2025 through August 31, 2029. The award funds research investigating the role of striatal interneurons in behavioral control and value-based decision-making. The project will employ viral-genetic tools and a head-fixed, value-based choice task to systematically examine...
- Federal Grant Award Summary Yale University received a $191,449 Mentored Career Development Award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective June 1, 2026 through May 31, 2031. The award supports rigorous training and research preparation for an early-career investigator to develop expertise in molecular neuroimaging applied to severe psychiatric conditions. The primary deliverables include: (1) intensive, focused...
Yale University received a $716,428 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded July 15, 2026, with completion targeted for July 14, 2030. This mentored career development award, led by Dr. Meghan Van Zandt, funds fundamental neuroscience research investigating sex differences in striatal regulatory interneurons—specifically cholinergic interneurons (CINs) and parvalbumin-expressing fast spiking interneurons (FSIs). The research addresses a critical gap in understanding why neuropsychiatric disorders including Tourette syndrome and autism display marked male-female differences in prevalence and symptom presentation. The project delivers three integrated research aims utilizing advanced neuroscience techniques. Aim 1 determines whether gonadal or genetic mechanisms underlie sex-based differences in striatal interneuron density and distribution using four-core genotype mice. Aim 2 characterizes anatomical and molecular properties through 3D morphological reconstruction, synaptic tracing analysis of interneuron networks, and single-nucleus RNA sequencing to examine gene expression patterns in both CIN and FSI populations. Aim 3 analyzes population activity of striatal interneurons during spontaneous behaviors using fiber photometry in male and female subjects. Collectively, these research products are expected to elucidate fundamental mechanisms underlying sexual dimorphism in interneuron function and provide mechanistic insight into sex-based prevalence disparities in neuropsychiatric disease.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $716.4k | 7/14/26 |