Project Grant K01DK140632
Award Date
9/1/24
Completion Date
8/31/29
Dollars Obligated
$136K
Similar Awards
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $934,946 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Virginia Commonwealth University (VCU). The grant supports research to investigate the role of the acid ceramidase-sphingosine-1-phosphate (AC-S1P) pathway in the kidney's regulation of sodium excretion and its potential contribution to salt-sensitive hypertension. Specifically, the research...
This Project Grant award of $1,107,090, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, supports research at The General Hospital Corporation (doing business as Massachusetts General Hospital) to investigate the regulation of G protein alpha subunit (Gsα) expression and its role in hormone signaling. The research aims to elucidate the mechanisms by which GNAS gene...
This Project Grant award of $1,188,167 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847, the Diabetes, Digestive, and Kidney Diseases Extramural Research program, supports research to develop inhibitors of the sphingosine 1-phosphate (S1P) signaling pathway as potential therapies for chronic kidney disease (CKD). The primary awardee, Virginia Polytechnic Institute & State University (Virginia Tech), will work to improve the oral...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to demonstrate the clinical utility of patient-reported outcome measures (PROMs) in the care of individuals with advanced chronic kidney disease (CKD). The $199,130 award will fund three key activities: 1) Developing and validating risk stratification models that incorporate PROM data to...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding the development and validation of an allysine-targeted positron emission tomography (PET) probe to noninvasively quantify renal fibrosis. The $1,447,749 award to The General Hospital Corporation (doing business as Massachusetts General Hospital) will support additional IND-enabling...
This Project Grant award of $340,822 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to determine the molecular and cellular mechanisms by which heparan sulfate controls parathyroid hormone-related protein (PTHrP) signaling via the PTH type 1 receptor (PTHR). The research aims to characterize the binding properties of PTHrP and heparin/heparan sulfate...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $168,886.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research titled "Elucidating the Role of NAD+ and PARylation in Nephron Endowment." The award aims to study how maternal availability of nicotinamide adenine dinucleotide...
This $675,480 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to develop a novel therapeutic compound for treating chronic kidney disease (CKD). The awardee, Fibrotherapeutics Inc., is conducting preclinical studies to evaluate the efficacy, safety, and therapeutic index of a modified, water-soluble, orally-active peptide derived...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $148,986 to the University of Pittsburgh to investigate the role of BK gamma subunits in regulating potassium secretion in the kidney. The award supports a 5-year research project focused on understanding how the BKγ2 subunit, which is highly expressed in intercalated cells, is...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $115,500 to Wayne State University to conduct research on the molecular mechanisms by which high-salt diets regulate the activity of the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the kidney. The research aims to identify novel E3 ubiquitin...