This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $136,350 in funding to the University of Chicago to study the neurobiological mechanisms underlying nicotine relapse and context-induced craving.
The primary objective is to use large-scale neural imaging techniques in mice to track hippocampal neuron activity and uncover how nicotine-context associations are formed and retrieved, as well as the role of nicotinic acetylcholine receptors in these processes. The research aims to provide a detailed understanding of how nicotine-driven memory representations in the hippocampus contribute to context-induced relapse. This mechanistic knowledge could help identify novel therapeutics and relapse-prevention strategies for nicotine dependence. The award period runs from June 1, 2024 to May 31, 2029.
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