The Medical University of South Carolina (MUSC) received a Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The $119,986 award, with a start date of May 15, 2024 and an end date of April 30, 2029, will fund research to define the epigenetic factors responsible for downregulation of the transcription factor KLF4 in systemic sclerosis-associated interstitial lung disease (SSc-ILD). The research aims to build a comprehensive regulatory network of differentially expressed genes, microRNAs, and long non-coding RNAs to identify and validate the role of these epigenetic modulators in KLF4 regulation. This work will support the development of therapeutic strategies to restore antifibrotic levels of KLF4 and prevent, stop, or reverse fibrosis progression in SSc-ILD.
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