Project Grant K01AI192505
- This federal Project Grant award of $853,537.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand how the fungal pathogen Aspergillus fumigatus uses melanin to evade the immune response in lung epithelial cells. The key objectives are to: [1] dissect the mechanism of how Aspergillus melanin inhibits chemokine secretion, [2] determine the signaling pathways affected by...
- The University of Texas Medical Branch at Galveston received a $489,965 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to conduct research on "IFN/SOCS1 Signaling During Post-Influenza Bacterial Infection". The project aims to investigate the role of IFN-I signaling and SOCS1 in suppressing the immune response to Streptococcus pneumoniae infection following influenza A virus infection. The research...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $147,486 Project Grant to Trustees of Dartmouth College to study how the hypoxia morphology of Aspergillus fumigatus (a common fungal pathogen) impacts diagnostic methods for invasive pulmonary aspergillosis (IPA). The key objectives are to 1) investigate how the hypoxia-induced gene HrmA regulates the production of antigenic polysaccharides,...
- This Project Grant award of $121,752 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research into enhancing the efficacy of echinocandin antifungal drugs for treating invasive pulmonary aspergillosis (IPA). The project aims to investigate the role of the Septation Initiation Network (SIN) kinase cascade, particularly the terminal kinase SIDB, in regulating septation and echinocandin...
- This $249,749 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to develop a new approach for analyzing transcriptional control of virulence in the human fungal pathogen Aspergillus fumigatus (AFu). The research team will express an anti-GFP nanobody fused to a mammalian E3 ligase enzyme to trigger proteolysis of GFP fusion proteins in AFu. They will prepare GFP fusion proteins to 8...
- This $226,500 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports research to understand the mechanisms of innate immunity against Pneumocystis pneumonia (PCP), a serious fungal infection affecting immunocompromised patients. The project utilizes mouse models to investigate how alveolar macrophages and lung epithelial cells contribute to rapid clearance of Pneumocystis in the absence of functional CD4+...
- This federal Project Grant award of $596,115 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the long-term impact of persistent parainfluenza virus infection. The research aims to expand understanding of the biology, ecology, and evolution of common respiratory viruses and their potential to drive chronic lung diseases like asthma. The 5-year project will be conducted by...
- This $838,320 Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant will fund research to investigate fungal pathogenicity determinants and their relationship to emerging cancer therapies that can lead to increased risk of invasive fungal infections. Specifically, the research aims to understand the mechanism by which inhibition of the Bruton's...
- This Project Grant, valued at $868,776.00 and awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), supports research to characterize a novel post-transcriptional regulator in the opportunistic pathogen Pseudomonas aeruginosa. The key objectives are to identify the direct regulatory targets of this regulator, called PhAF, under standard laboratory conditions and in clinically relevant...
- This $224,070 federal Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), with a performance period from Feb 2025 to Mar 2027. The grant supports research at the University of Utah to investigate the mechanisms by which co-infection with influenza protects against malaria-associated respiratory distress syndrome (MA-ARDS) in mice. The research aims to determine how influenza...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $152,097 to The University of Texas MD Anderson Cancer Center to conduct research on influenza- and respiratory syncytial virus-associated pulmonary aspergillosis (IAPA/RSV-APA), which are deadly secondary mold infections in immunocompromised patients. The research aims to characterize the post-viral impairment of anti-Aspergillus immune defense and evaluate the protective effects of nebulized immunotherapy using TLR2/6/9 agonists or GM-CSF, with or without systemic antiviral or antifungal therapy. The findings from this comprehensive preclinical study are intended to facilitate future clinical translation of immunomodulatory therapies to protect high-risk patients from deadly secondary mold pneumonias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $152.1k | 8/27/25 |