Project Grant K01AG090692
- This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research provides $133,353 to Mayo Clinic to investigate the molecular mechanisms of T cell-mediated surveillance of senescent cells under both physiological and aging conditions. The research aims to define how senescent cells deploy their secretome to sensitize human T cells, assess co-stimulatory and co-inhibitory interactions between senescent cells and T cells, and perform translational studies...
- This $2,591,620 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to Cedars-Sinai Medical Center in California. The grant is designed to determine the role of hypothalamic neurons in the progression of physiological decline with age, with a focus on understanding the cellular mechanisms responsible for increased frailty in older adults. Key objectives include elucidating the role of arginine-vasopressin (AVP) neurons...
- This federal Project Grant award of $291,913 was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to Virscio, Inc., a for-profit research company located in Connecticut. The award is focused on developing epigenetic and senescent biomarkers using non-human primate tissues to advance the understanding of biological aging processes and potential anti-aging strategies. The project aims to create minimally invasive biomarker tools, such as blood and skin-based assays,...
- This $147,486 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research to investigate the role of chaperone-mediated autophagy (CMA) in cellular senescence and its contribution to aging. The research aims to understand: 1) if CMA activity changes upon induction of senescence, 2) if CMA modulates senescence kinetics and by what mechanism(s), 3) if CMA is required for senescent cell clearance, and 4) if restoring CMA activity...
- This federal Project Grant award of $438,625.00 from the National Institute on Aging (CFDA 93.866 Aging Research) to Brown University aims to study how the cellular senescence phenotype changes over time and develop technology to track the duration of cells in senescent states. The key objectives are to (1) examine how the senescence phenotype, including the senescence-associated secretory phenotype (SASP), evolves from early to deeper states, and (2) advance a multi-symbol molecular recorder...
- This federal Project Grant award of $240,069 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University will be used to explore the effects of lifestyle on immune system activity and molecular markers of aging across populations with diverse lifestyles, from traditional subsistence-level to highly urban. The research will focus on analyzing three age-associated molecular phenotypes - gene expression, DNA methylation, and telomere length - in peripheral blood...
- The National Institute on Aging (NIA) awarded a $1,466,297 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Cedars-Sinai Medical Center, in collaboration with the University of California Los Angeles (UCLA) and the University of Southern California (USC), to establish the Los Angeles Claude D. Pepper Older Americans Independence Center (LA OAIC). This 5-year grant, effective September 1, 2025, aims to extend human healthspan by accelerating and expanding...
- This $789,664 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a research project titled "Dissecting the Cellular and Spatial Tissue Clock of the Human Lung and Peripheral Blood" at the Icahn School of Medicine at Mount Sinai. The project aims to leverage single-cell RNA sequencing and spatial transcriptomics to characterize the effect of age on the cellular microenvironment of the human lung and peripheral blood. The research will...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,208,503.00 to Cornell University to conduct research on the role of autophagy in cellular aging. The project, titled "System-wide and Mechanistic Deconvolution of Autophagy in Cellular Aging", aims to systematically investigate how different forms of autophagy influence cellular aging processes, with a focus on understanding how modulating selective autophagy pathways such...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,492 to Weill Medical College of Cornell University to support research focused on identifying and characterizing clonal expansions in aging and aging-related diseases. The key products/services to be delivered under this award include: Developing tools to enable the identification of candidate somatic variants at scale from publicly available data using machine learning approaches. Applying...
This federal Project Grant award in the amount of $124,875.00 was provided by the National Institute on Aging (CFDA 93.866 Aging Research) to Cedars-Sinai Medical Center. The grant supports research by Dr. Larissa Langhi Prata, an Assistant Professor at the Kogod Center on Aging at Mayo Clinic, to investigate the role of senescent cells in the susceptibility of elderly and chronically ill patients to infectious diseases. The research aims to provide insights into the biology of aging and its connections to the immune system, potentially leading to novel strategies for addressing this major health problem. The grant will fund Dr. Langhi Prata's career development, including training in immunological assays, digital pathology, and laboratory management, as well as collaborations with leading experts in cellular senescence and immunology. The project has an ultimate completion date of May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $124.9k | 9/3/25 |