Project Grant HT94252410096

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 24-month, $430,375 Project Grant (CFDA 93.853) to Emory University to develop human organoid models for pediatric high-grade gliomas (PHGGs). The research aims to 1) create PHGG organoid models using human patient-derived cancer stem cells and 2) model how interactions between PHGG cells and the human neural microenvironment affect responses to tyrosine kinase inhibitors and other anti-tumor drugs. The goal is to...

This Project Grant award of $248,999 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to The Washington University will leverage patient-specific induced pluripotent stem cell (iPSC)-derived cardiac pericytes and endothelial cells to elucidate the molecular and cellular basis of tyrosine kinase inhibitor-induced vascular toxicity (TKI-VT) and discover personalized therapies. The key objectives are to: Characterize sunitinib-induced cytotoxicity...

This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $127,305 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to conduct research on "Unraveling Immune Cell Interactions and Multicellular Dynamics in GNAQ-Driven Capillary Malformation". The research aims to determine the role of macrophages in capillary malformations caused by a specific GNAQ gene mutation, as well as...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $776,511 to the Fred Hutchinson Cancer Center (Seattle, WA) to develop a 3D engineered hemogenic vascular niche model that supports the induction of hematopoietic fates from human pluripotent stem cell-derived endothelium. The primary objective is to leverage this innovative platform to investigate how intrinsic arterial...

This Project Grant award of $143,788 from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) supports research on genetic dependencies in pediatric low-grade gliomas (PLGG) with KIAA1549-BRAF rearrangements. The primary goals are to understand how the KIAA1549:BRAF fusion is activated, and why the POMT complex is essential for the survival of KIAA1549:BRAF-dependent cells. The research will test hypotheses related to the role of POMT enzymatic activity,...

This $443,354 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to investigate targeting the hexosamine biosynthetic pathway as a potential treatment for pediatric brain tumors. The research aims to understand how this metabolic pathway supports the growth and apoptosis resistance of diffuse midline gliomas with the...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $461,528 to the University of Connecticut Health Center (UCHC) to create the first human-based cellular model of Hao-Fountain syndrome. The goal is to understand the effect of disease-linked mutations on the enzymatic function of USP7 and on neuron differentiation and morphology....

Trustees of Tufts College, doing business as Tufts University School of Medicine, received a $453,750 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding will support research to define the potential of gene therapy to correct motor disabilities associated with CTNNB1 syndrome, a rare genetic disorder characterized by intellectual...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $160,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to Children's Hospital Medical Center in Cincinnati, Ohio. The grant supports research to investigate the epigenetic mechanisms underlying neurodevelopmental defects in Menke-Hennekam Syndrome, a rare genetic disorder caused by mutations in the EP300 gene. The project aims to (1) identify maturation and...

This $178,000 Project Grant awarded by the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH), aims to develop a bone marrow organoid system to study RUNX1-familial platelet disorder with associated myeloid malignancy (RUNX1-FPD/MM). RUNX1-FPD/MM is a rare genetic disorder that can lead to thrombocytopenia, platelet dysfunction, and a high risk of developing myelodysplastic syndrome and leukemia. The project, awarded to The...