Project Grant F32CA306227
- The National Cancer Institute (NCI) awarded a $619,628 Project Grant under the Cancer Biology Research program (CFDA 93.396) to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania. The funding will support the development and validation of an autologous mouse model to study immune system interactions with glioblastoma, a type of brain cancer. The goal is to create a humanized mouse system that incorporates patient-derived tumor...
- The University of California, San Diego received a $662,682 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) to investigate the prognostic and therapeutic roles of voltage-gated potassium channels in managing KIT mutant gastrointestinal stromal tumors (GIST). The research aims to determine the safety, tolerability, and efficacy of combining the tyrosine kinase inhibitor imatinib with the potassium channel blocker 4-aminopyridine...
- This $110,550 Project Grant award from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) supports research on the mechanisms of lymphatic metastasis in pancreatic ductal adenocarcinoma. The primary aim is to investigate transient, single lymph node regulatory T cell depletion as a potential therapeutic strategy to treat lymph node metastasis. The project is being conducted by the Trustees of the University of Pennsylvania, a prominent private research university,...
- The University of Pennsylvania received a $667,533 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) to conduct research on an innovative multimodal approach using radiation therapy (RT), chimeric antigen receptor T-cell (CART) therapy, and gut microbiome modulation for treating lymphoma. The research builds upon the university's previous groundbreaking findings, published in 2020 and 2023, which demonstrated the synergistic antitumor...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $483,760 to The Trustees of the University of Pennsylvania to conduct research on understanding the role of the DCAF15 protein in acute myeloid leukemia (AML). The primary objectives are to (A) decipher the biological function of DCAF15 in myeloid development and leukemia in vivo, (B) investigate the role of cohesin acetylation in AML pathogenesis, and (C) develop small molecule...
- The University of Pennsylvania, through its Clinical Practices division, was awarded a $812,500 Project Grant from the Department of Defense's Military Medical Research and Development program (CFDA 12.420) to conduct research on "Targeting UGCG in the Melanoma Tumor Microenvironment." This 3-year research project, which commenced on September 1, 2024, aims to investigate innovative approaches to treating melanoma, a serious form of skin cancer, with a focus on modulating the tumor...
- This Project Grant award of $1,625,000 from the U.S. Department of Defense's Military Medical Research and Development program (CFDA 12.420) supports in-vivo mechanistic characterization of the angiogenic immune checkpoint in liver cancer at the Trustees of the University of Pennsylvania. The research aims to advance scientific understanding and develop solutions for this important health challenge. The award commenced on September 1, 2023 and is scheduled for completion by August 31, 2027. As a...
- The University of Pennsylvania received a $597,766 Project Grant from the National Cancer Institute (CFDA Program 93.394 - Cancer Detection and Diagnosis Research) to develop methods for dual-tracer multiparametric imaging with a long-axial field-of-view PET scanner. The project aims to enable the simultaneous imaging of two different PET radiotracers in a single session, which would improve the characterization of cancer and transform precision medicine guided by molecular imaging. The 5-year...
- This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) to Georgetown University for $109,386 provides funding to investigate strategies to increase the co-localization of activated natural killer (NK) cells with tumor cells in pancreatic ductal adenocarcinoma (PDAC). The research aims to explore how inhibiting dipeptidyl peptidases (DPPs) can enhance the efficacy of anti-PD1 immunotherapy by increasing NK cell infiltration and reducing fibrosis in...
- This $616,897 Project Grant was awarded on August 8, 2025 by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant supports the development of synthetic compartments that can insulate and sequester signaling components to rewire inflammatory signaling and restore immune cell function. Key objectives include insulating and shutting down components of...
The University of Pennsylvania received a $160,040.00 Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) on January 16, 2026 to study the role of the Dectin-1 pattern recognition receptor in the immune response to gastrointestinal stromal tumors (GISTs). The project aims to determine if activation of Dectin-1 on tumor-associated macrophages and dendritic cells can stimulate antitumoral immunity and synergize with imatinib therapy, including in imatinib-resistant GISTs. The research will involve flow cytometry, RNA sequencing, and in vitro functional experiments on immune cells derived from mouse and human GIST models to evaluate the direct effects of the Dectin-1 agonist D-zymosan. The project will also assess the anti-tumor efficacy of Dectin-1 activation in a mouse GIST model. This work seeks to leverage innate immunity to improve treatment options for GIST patients.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 7/16/25 | ||
| Not listed | $80.0k | 7/16/25 | ||
| Not listed | $80.0k | 7/16/25 |