Project Grant F32AI195016
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Salk Institute for Biological Studies a Project Grant of $188,208 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for structural and biochemical studies of human immunodeficiency virus (HIV) and mouse mammary tumor virus (MMTV) retroviral integration. The award, obligated on October 24, 2025, with completion scheduled for June 30, 2028, supports research to elucidate...
- This Project Grant award, valued at $859,992.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to Yale University. The research project, titled "Molecular Investigations of HIV-1 Maturation Pathways and Inhibitor Actions in Situ," aims to use advanced cryo-electron microscopy techniques to visualize the structural transitions of the HIV-1 virus during the...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $258,200 to The Regents of the University of Colorado (University of Colorado-Denver) under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 22, 2025, with a completion date of June 30, 2027. This Project Grant funds investigator-initiated biomedical research examining HIV-1 integrase interactions with viral RNA, specifically investigating the non-catalytic...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Utah $743,752 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2030. This five-year Project Grant funds investigator-initiated research examining the epigenetic programming of CD4+ helper T cells during chronic viral infection. The research will investigate how persistent antigen stimulation and...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Alabama at Birmingham $128,451 through the Allergy and Infectious Diseases Research program (CFDA 93.855) on November 3, 2025, for a project extending through June 30, 2028. This F31 predoctoral fellowship grant supports research investigating the structural basis for HIV-1 Rev nucleocytoplasmic trafficking—specifically how the HIV-1 Rev protein is recognized, bound, and...
- Federal Grant Award Summary The University of Utah, through its Office of Sponsored Projects Division, received a $156,080 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded November 23, 2025, with a completion date of June 30, 2028. This research project, titled "Innate Cells with Adaptive Specificity: Bond Kinetics of NK Cell Inhibitory Receptor Ly49C," supports...
- This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the dynamics and evolution of HIV Gag and GagPol processing. The $752,745 award aims to use molecular dynamics simulations, single-molecule FRET imaging, and cryo-electron tomography to probe the structure and dynamics of Gag and GagPol that enable ordered processing by the viral...
- This Project Grant award of $603,338, obligated July 3, 2025, and administered by the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), funds research conducted by Yale University through June 30, 2030. The grant supports investigation of HIV-1 (Human Immunodeficiency Virus 1) fusion mechanisms on native membranes using cryo-electron tomography (CryoET) and molecular dynamics (MD) simulations. The research aims to...
- This $624,902 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports research to investigate how the HIV accessory protein Vpr induces epigenetic remodeling in myeloid cells, which may contribute to HIV persistence. The research aims to characterize the functional impact of Vpr-directed epigenetic remodeling on the HIV promoter during acute infection and latency reactivation, delineate the mechanisms of...
- Federal Project Grant Award Summary Northwestern University's Sponsored Research Division received a $156,160 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective September 1, 2025, through August 31, 2027. The award supports a two-year independent research initiative focused on elucidating the structural basis of HIV-1 accessory proteins, specifically the viral proteins Vpr and...
The University of Utah's Office of Sponsored Projects received a $150,104 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective January 22, 2026, through August 31, 2028. This fellowship award (F32 postdoctoral award) funds research designed to elucidate the mechanistic role of HIV-1 integrase (IN) in viral maturation and RNA encapsidation. The research employs complementary structural biology and biophysical techniques to investigate the binding interactions between IN and capsid (CA) proteins, with particular focus on how IN bridges viral genomic RNA and assembling capsid hexamers. The funded research aims to produce detailed mechanistic understanding of HIV maturation processes through investigation of IN-CA binding schemes and their structural effects on capsid organization. Preliminary findings suggest that IN binds to the C-terminal domain of CA, inducing shifts in protein-protein organization during capsid assembly. Successful completion of this research is expected to advance fundamental understanding of HIV maturation biology and potentially identify new antiviral targets by clarifying how IN functions as a critical structural component during viral replication and infection.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $75.1k | 7/23/25 | ||
| Not listed | $0 | 7/23/25 | ||
| Not listed | $75.1k | 7/23/25 |