Project Grant F32AI194777
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $653,693 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to Emory University to conduct research on the structural details of immature and mature HIV-1 viral assembly and capsid mechanics. The research will leverage cryo-electron microscopy and related techniques to gain a deeper understanding of the molecular determinants governing these viral processes, with the goal of...
- This $877,104 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the molecular mechanisms of Kaposi's Sarcoma-associated Herpesvirus (KSHV) infection and persistence. The grant funds computational analyses of bulk and single-cell RNA sequencing data from KSHV-infected monocytes, macrophages, and B cells to understand how the virus impacts these...
- This federal Project Grant award, valued at $402,150.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The award supports research to investigate the mechanisms by which the Kaposi's sarcoma-associated herpesvirus (KSHV) promotes its lytic reactivation cycle through binding to host cell forkhead-associated (FHA) domains. The research aims to uncover viral protein-host protein interaction...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $430,285 Project Grant to Towson University to investigate RTA-induced ubiquitination in Kaposi's Sarcoma Herpesvirus (KSHV) for the period of February 1, 2025 to January 31, 2028. The project aims to identify cellular targets for intervention by studying novel virus-host interactions involving the cellular ubiquitin-proteasome...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $102,534 to Yale University to conduct research aimed at elucidating the molecular function of the Kaposi's sarcoma-associated herpesvirus (KSHV) packaging accessory protein ORF68. The research project, spanning from January 2025 to August 2027, seeks to determine the oligomeric state of ORF68 during KSHV...
- This federal Project Grant award from the National Institutes of Health (NIH), under the Trans-NIH Research Support (CFDA 93.310) program, provides $1,367,863 to Emory University to conduct biophysical research on herpesvirus capsid assembly and genome packaging. The goal is to develop new methodologies to monitor these essential viral processes in real-time, which could lead to a more complete understanding of herpesviral replication and the development of improved preventative and...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $650,934 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University in St. Louis, Missouri. The grant supports research to elucidate the molecular mechanisms by which the HIV Gag protein interacts with and sequesters the CARD8 inflammasome, a key component of the innate immune system that recognizes the HIV protease. The goal is to develop a detailed...
- The National Institute of Allergy and Infectious Diseases (NIAID), through its Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), awarded a $238,972 Project Grant to The Research Foundation For The State University Of New York (RF SUNY) to study the role of the cellular protein EHD4 in restricting HIV-1 infection. The research aims to determine the mechanism by which EHD4 decreases HIV-1 particle infectivity and reduces the incorporation of viral envelope glycoproteins...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $236,292 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Tufts University School of Medicine to conduct research on the herpes simplex virus (HSV) entry glycoprotein complexes. The key objectives are to use new methods to isolate and characterize the structures of HSV glycoprotein complexes, such as GD/GH/GL and GH/GL/GB, which are critical for viral entry into host cells. This...
- This $109,941 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the role of caspase-3 mediated cleavage of VPS4A in restricting herpes simplex virus 1 (HSV-1) replication. The University of Massachusetts Medical School is the awardee and will conduct the research in Worcester, MA. The study aims to elucidate the mechanisms by which caspases and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $156,104 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to Emory University. The grant supports research to understand the capsid assembly mechanisms of Kaposi Sarcoma-associated Herpesvirus (KSHV), a leading cause of cancer in HIV-positive individuals. The research aims to develop an in-vitro capsid assembly assay to monitor the kinetics and oligomeric states required for KSHV capsid nucleation and maturation. The project period is from February 28, 2026 to February 27, 2027. The research outcomes may contribute to the development of pan-herpesvirus therapeutics by leveraging the conserved nature of major capsid proteins across herpesvirus subfamilies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 1/2/26 | ||
| Not listed | $78.1k | 8/29/25 | ||
| Not listed | $78.1k | 8/29/25 |