This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $848,839 to the University of Massachusetts Medical School (UMass Medical) to investigate new mechanisms by which HIV accessory proteins mediate control of natural killer (NK) cell function. The key objectives are to identify novel HIV-regulated NK cell ligands, define how the HIV Vif protein regulates MHC-I...
This Project Grant award of $666,567 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by the University of California, Los Angeles (UCLA) to investigate the transcriptional regulation of human natural killer (NK) cell function in response to viral infections, such as human cytomegalovirus (HCMV). The key objectives are to determine the mechanisms by which the transcription factor MEF2C regulates NK cell...
This $423,500.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at the University of Utah to investigate the role of invariant natural killer T (iNKT) cells in shaping the immune response to Plasmodium infection, which can lead to the severe neurological condition of cerebral malaria. The research aims to define how the T cell receptor (TCR) signaling properties of different iNKT cell...
This Project Grant award of $423,500 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at the University of Utah focused on developing and evaluating bispecific killer cell engager (BiKE) antibodies that can effectively deplete programmed death-1 (PD-1) positive cells. The goal is to mitigate autoimmune disease progression by selectively eliminating disease-causing PD-1-expressing lymphocytes while preserving...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $318,085 to support research on the role of antibodies in controlling virus infections through Fc-dependent mechanisms such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytolysis (CDC). The research aims to elucidate the...
The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $223,068 Project Grant to Loyola University of Chicago to investigate the origin, differentiation, and function of tissue-resident natural killer (NK) cells in the uterine mucosa. The 2-year project, running from July 2025 to June 2027, aims to elucidate the signals that drive the differentiation of circulating NK cells into...
This Project Grant award, totaling $764,591, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project aims to study the differential regulation of cell cycle entry and apoptosis in cytolytic lymphocytes, particularly natural killer (NK) cells, with a focus on understanding how genetic variants affecting DNA replication (the "replisome") can impair NK cell function. The...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under CFDA 93.855 - Allergy and Infectious Diseases Research, provides $109,671.00 to the University of Massachusetts Medical School (UMass Medical) to characterize mechanisms by which HIV-infected macrophages resist natural killer (NK) cell-mediated killing. The research aims to define macrophage-specific mechanisms that increase resistance to NK cell-mediated killing, focusing on: 1)...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $220,000 to the Fred Hutchinson Cancer Center to conduct research on natural killer (NK) cell memory responses to HIV. The key objectives are to use a novel lineage tracing method called ASAP-seq to identify and characterize long-lived, HIV-specific NK memory cell clones in a unique longitudinal cohort of...
This $649,053 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research by The Washington University to investigate the role of Ly49 family receptors on CD8 T cells. The central hypothesis is that immunization expands the sub-population of CD8 regulatory T cells (Tregs) that can resolve immune responses, and that Ly49 and the transcription factor Helios...