This federal Project Grant award in the amount of $765,274 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research to investigate the mechanisms by which defective HIV proviruses in CD4+ T cells and macrophages perpetuate chronic inflammation and contribute to HIV comorbidities, even among patients receiving antiretroviral treatment.
The primary awardee, Boston...
This federal Project Grant award of $854,360.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award will support research to investigate the role of post-transcriptional RNA modifications in HIV-associated chronic inflammation in people living with HIV on antiretroviral therapy. The primary recipient, Trustees of Boston University, will lead efforts to determine the molecular...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $197,366 to The Washington University to conduct research on understanding the mechanisms that allow the human immune system to naturally restrict a specific subset of the HIV virus. The 5-year study aims to:
Characterize the molecular mechanisms driving the restriction of X4-tropic HIV replication in the presence of R5-tropic...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $752,745.00 in funding to the University of Massachusetts Medical School (UMass Medical) to support research on the dynamics and evolution of HIV Gag and GagPol protein processing.
The key objectives of this 1-year project are to use molecular dynamics simulations, single-molecule FRET imaging, and...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $1,704,356 to Brigham & Women's Hospital to conduct research on immune selection of HIV-1 reservoir cells. The funding aims to leverage cutting-edge single-cell analysis techniques to study the interplay between HIV-1 reservoir cells and the host immune system in three recent clinical trials. Key objectives include identifying...
This $220,224 Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project aims to computationally investigate three key morphological transitions in the HIV-1 life cycle - assembly and budding of the immature virion, maturation of the viral core, and uncoating - with a focus on the role of factors beyond the capsid domain proteins, including RNA, host cell factors,...
This federal Project Grant award of $500,475.00, administered by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), supports research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) to investigate the host-dependent mechanisms that guide the longitudinal dynamics of SIV (Simian Immunodeficiency Virus) integration. The research project aims to generate an atlas of SIV integration sites and characterize the impact of host...
This $1,041,232 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to better understand the barriers to HIV eradication in lymph nodes and the gut. The primary awardee, The General Hospital Corporation (Massachusetts General Hospital), will use advanced imaging and omics technologies to characterize the cellular and molecular processes that impede immune-mediated elimination of HIV in...
This federal Project Grant award, under the Allergy and Infectious Diseases Research program (CFDA 93.855) administered by the National Institute of Allergy and Infectious Diseases, is providing $2,993,935.00 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to study the structural and functional properties of the HIV-1 fusion complex, both alone and when bound to fusion inhibitors, in a lipid bilayer membrane. The goal is to develop a "molecular...
This $218,900 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research program) supports research to elucidate the proteolytic determinants of flavivirus infection. The project aims to investigate the molecular factors that influence flavivirus protease cleavage of intracellular substrates and how these factors impact viral fitness. Key research activities include testing the impact of substrate...