The Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $125,160.00 to The Ohio State University to characterize a novel bacterial immune system with unknown mechanisms. The project aims to use cryogenic electron microscopy and biochemical/cellular assays to define the structure, assembly, and functions of a two-component system (Component A and Component B) involved in...
This $173,030 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will develop a novel assay for receptor-guided discovery of environmental bacteriophages (phages). The goal is to create a generalized method to preferentially isolate phages that require specific bacterial membrane proteins or structures for infection. This could be useful for understanding bacterial membrane dynamics...
This Project Grant award, valued at $151,531, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research to investigate the mechanisms of reverse transcriptase-mediated phage defense systems in Enterobacteriaceae, a group of multidrug-resistant bacteria that pose a significant public health threat. The project aims to develop an experimental approach to discover the RNA...
This federal Project Grant award, valued at $453,900.00 and granted by the National Institute of Allergy and Infectious Diseases (NIAID), supports research to develop a universal bacterial genome editing platform using broad-specificity phage recombinases. The project aims to overcome the limitations of current genetic engineering tools, which are typically restricted to laboratory-adapted bacterial strains, by leveraging conserved phage proteins to enable genetic manipulation across a wide...
The federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research into the role of the sigma factor SigE in mycobacterial granulomas. This $207,370 award to Duke University, effective from September 21, 2024 through March 31, 2027, aims to uncover novel bacterial elements that impact the survival of mycobacteria within granulomas and the associated host...
This federal Project Grant award, valued at $104,552.00 and awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program, funds research aimed at understanding how the tuberculosis-causing bacterium Mycobacterium tuberculosis (MTB) is able to survive and thrive within human neutrophils, the most abundant immune cells recruited to sites of MTB infection. The key objectives of this project are to: 1)...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $206,251 to Duke University to investigate the molecular mechanisms and pathophysiology of Salmonella Typhimurium infection. The research aims to elucidate how the bacterial effector protein SARA manipulates the host STAT3 signaling pathway to promote anti-inflammatory responses and enhance the pathogen's...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $442,024 to Trustees of Dartmouth College to conduct research on the molecular characterization and modeling of efficient antibody effector function. The research aims to elucidate the cellular mechanisms that drive advancements in the development of immune therapeutics and the parameters that influence the outcome...
This $769,115 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to advance understanding of how neurotropic viruses, such as flaviviruses and alphaviruses, can directly enter the central nervous system (CNS) through newly described meningeal structures called arachnoid cuff exit (ACE) points. The research will explore how early-life neurotropic virus...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $226,253 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University in St. Louis, Missouri. The award supports research to mechanistically understand how the host protein ADAM10 modulates interactions between neutrophils and the endothelium in the context of Staphylococcus aureus infection. The research aims to generate a spatiotemporal analysis of these cellular...