This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $126,096 to the University of California, San Diego (UCSD) for research focused on understanding the mechanisms of microbial competition between Salmonella typhimurium and the gut microbiome. The research aims to elucidate the metabolic interactions and host responses that influence Salmonella colonization, with the...
This Project Grant award, titled "MECHANISMS OF LIPID A MODIFICATION IMPACTING ANTIMICROBIAL RESISTANCE", is funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $569,210 award, spanning February 1, 2025 to January 31, 2030, supports research to characterize key enzymes responsible for conferring antimicrobial resistance in Gram-negative bacteria through lipid A modifications. The...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is funding a research project focused on the discovery and engineering of microbial enzymes that can modulate peptidoglycan metabolites in the gut microbiome. The primary objectives are to identify highly active, secreted, and stable peptidoglycan-degrading enzymes (Aim 1) and develop genetically engineered probiotic...
This $891,678 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify and characterize the mechanisms by which metabolites produced by intestinal microbiota, specifically bile acids, modulate host immune responses. The multi-disciplinary research team at the Scripps Research Institute will employ innovative chemical biology and proteomic approaches to...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $749,417 to support research focused on developing novel bactericidal antibiotics to address the growing problem of multi-drug resistant pathogens. The research team at Harvard University aims to synthesize and evaluate new antibiotic candidates that target the lipoprotein transport pathway in Gram-negative...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the newly discovered ability of the protein calprotectin to hydrolyze and inactivate certain β-lactam antibiotics such as ampicillin, amoxicillin, and oxacillin. The $784,059 award, effective July 23, 2024 through June 30, 2029, will be executed by the University of North Carolina at Chapel...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $212,169 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Johns Hopkins University to advance mentorship and research in antimicrobial resistance (AMR). The grant supports the awardee's efforts to expand their knowledge of molecular mechanisms of antibiotic resistance, incorporate new research techniques into their lab, and provide mentorship to trainees conducting both...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $506,394.00 in funding to the University of Chicago to conduct research on bacterial cholesterol-dependent cytolysins (CDCs) and their role in activating the NLRP3 inflammasome. The research aims to define the specific molecular and cellular mechanisms by which CDCs can reorganize host organelles to stimulate the NLRP3...
This federal Project Grant award of $451,292 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) seeks to uncover neuronal mechanisms that orchestrate metabolic adaptations to bacterial infections, with a focus on delineating the role of the brain-liver axis in modulating these responses. The research aims to better understand how neuronal and hepatic (liver) processes regulate circulating lipid levels...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is funding research at Prokaryotics Incorporated to develop novel antifungal inhibitors targeting the glycosylphosphatidylinositol (GPI) biosynthesis pathway. The $170,000 award, running from February 1, 2025 to January 31, 2027, supports structural elucidation of the C. albicans GPI ethanolamine phosphate transferase enzyme...