Genetic and cellular mechanisms underlying resistance to gammaherpesvirus infection
Active Project Grant Awarded Last action
- Award ID
- F31AI194775
- Recipient
-
University Of Vermont & State Agricultural College UEI Z94KLERAG5V9
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $34,654
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date 0% complete
- Place of performance
- Burlington, VT 05405, USA
Award details come from USAspending.gov.
Description
- Abstract
- Chronic infection with the gammaherpesvirus epstein-barr virus (EBV) represents a risk factor for several cancers and autoimmune diseases. However, the role of host genetic variation in the regulation of immune responses to chronic gammaherpesvirus infection and control of viral replication remains unclear. We previously identified the wild-derived mouse strain PWD/PHJ (PWD) to have superior control of viral load compared to C57BL/6J (B6) mice at both early and late time points during infection with MHV-68, a murine gammaherpesvirus homologous to EBV. To further examine the role of host genetics on gammaherpesvirus infection outcomes, we completed a genetic screen of C57BL/6J-chrpwd chromosome substitution (CONSOMIC) mice and identified C57BL/6J-CHR17PWD (CHR17FPWD) CONSOMIC mice as a strain having superior viral control compared to B6 mice. We further narrowed the locus on CHR 17 to an interval at 27.6-49.4 MB, which includes the MHC locus. The focus of this proposal is to 1) refine the CHR 17 locus regulating MHV-68 control and 2) investigate the dynamics of MHV-68 B cell infection and latency in genetically resistant hosts. In direct support of the proposed studies, the training plan will develop knowledge, expertise, scientific communication skills, and technical abilities in 1) using forward genetics to establish novel mouse models of gammaherpesvirus infection, 2) immunology, with a focus on B cell and germinal center dynamics, and 3) bioinformatics with a focus on genetic mapping via quantitative trait locus analysis. The training environment at the university of vermont (UVM) is ideally suited to support this proposal as IT fosters interdisciplinary collaboration, provides access to state-of-the-art facilities, and stresses active mentorship.
Quick answers
Who received award F31AI194775?
F31AI194775 was awarded to University Of Vermont & State Agricultural College by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on February 10, 2027.
How much is award F31AI194775 worth?
$34,654 has been obligated on F31AI194775.
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