Project Grant DP5OD037346

Award Date 9/18/24
Completion Date 7/31/29
Dollars Obligated $406K
Funding Federal Agency
Office of the Director
Federal Grant Program
93.310
Assistance Type
Project Grant
Place of Performance
Philadelphia, PA 19104, USA
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  1. Define the tumor and stromal features that influence CAR T cell infiltration and function.
  2. Determine the impact of CAR T cell functional profile on myeloid tumor stroma.
  3. Determine the impact of CAR T cell functional profile on tumor cell plasticity and antigenicity.

The research will leverage spatial multi-omic analysis of tumor specimens from five CAR T cell clinical trials focused on pancreatic cancer, prostate cancer, and non-Hodgkin lymphoma. This comprehensive analysis aims to identify key pathways influencing CAR T cell response, resistance, and toxicity in solid tumors, informing the development of next-generation CAR T cell therapies. The award period runs from September 18, 2024 to July 31, 2029.

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