The University of Illinois has been awarded a $1,427,400 Project Grant by the National Institutes of Health (NIH) under the Trans-NIH Research Support (CFDA 93.310) federal grant program. The grant supports research aimed at establishing a multidimensional model of the interaction between astrocytes and distinct neuronal subpopulations within the prefrontal circuit. The research will integrate techniques for genetic/chemogenetic manipulation of astrocytic signaling and in vivo Ca2+ imaging of neuronal activities in freely behaving mice to reveal the functional, structural, and proteomic basis of astrocyte-neuron interaction. This research has the potential to inspire the development of novel therapeutics targeting astrocyte-neuron interactions to treat a wide range of brain disorders. The award period runs from September 1, 2023 to August 31, 2026.
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