This $1,449,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to study the fundamental regulation of extrachromosomal DNA (ecDNA) in cancer genomes. The project aims to develop new live-cell chromatin labeling strategies and integrate advanced imaging, synthetic genome engineering, and optical/genetic perturbation to systematically investigate how ecDNA orchestrates massive oncogene transcription, chromosomal remodeling, and asymmetric segregation. This high-risk, high-reward research has the potential for a transformative impact on understanding cancer genome regulation and uncovering new therapeutic approaches targeting ecDNA-driven cancer. The award was made to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, a private non-profit university, starting on September 1, 2023 with an end date of August 31, 2026.
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