The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant totaling $1,385,226 to The Leland Stanford Junior University (Stanford University) under the Biomedical Research and Research Training program (CFDA 93.859). The grant, spanning from September 1, 2023 to August 31, 2026, will support research to map and therapeutically hijack the trafficking of extracellular proteins to the lysosome, a key cellular process involved in regulating cell surface protein function, recycling, and degradation. The research aims to develop a comprehensive atlas of proteins that traffic to the lysosome, facilitating the rational utilization of new trafficking pathways for targeted protein degradation therapies across various diseases. This effort will leverage novel technologies for whole lysosome isolation, chemoproteomics, and de novo protein design to advance the understanding and therapeutic targeting of extracellular-to-lysosome communication.
Generated 7/16/24, 3:30 AM